PMID- 29137117
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2227-7382 (Print)
IS  - 2227-7382 (Electronic)
IS  - 2227-7382 (Linking)
VI  - 5
IP  - 4
DP  - 2017 Nov 11
TI  - A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of 
      Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise 
      Training.
LID - 10.3390/proteomes5040030 [doi]
LID - 30
AB  - We performed a systematic review and meta-analysis of proteomics literature that 
      reports human skeletal muscle responses in the context of either pathological 
      decline associated with obesity/T2DM and physiological adaptations to exercise 
      training. Literature was collected from PubMed and DOAJ databases following 
      PRISMA guidelines using the search terms 'proteom*', and 'skeletal muscle' 
      combined with either 'obesity, insulin resistance, diabetes, impaired glucose 
      tolerance' or 'exercise, training'. Eleven studies were included in the 
      systematic review, and meta-analysis was performed on a sub-set (four studies) of 
      the reviewed literature that reported the necessary primary data. The majority of 
      proteins (n = 73) more abundant in the muscle of obese/T2DM individuals were 
      unique to this group and not reported to be responsive to exercise training. The 
      main response of skeletal muscle to exercise training was a greater abundance of 
      proteins of the mitochondrial electron transport chain, tricarboxylic acid cycle 
      and mitochondrial respiratory chain complex I assembly. In total, five proteins 
      were less abundant in muscle of obese/T2DM individuals and were also reported to 
      be more abundant in the muscle of endurance-trained individuals, suggesting one 
      of the major mechanisms of exercise-induced protection against the deleterious 
      effects of obesity/T2DM occurs at complex I of the electron transport chain.
FAU - Srisawat, Kanchana
AU  - Srisawat K
AD  - Research Institute for Sport and Exercise Sciences, Liverpool John Moores 
      University, Liverpool L3 3AF, UK. k.srisawat@2015.ljmu.ac.uk.
AD  - Bureau of Non-Communicable Diseases, Department of Diseases Control, Ministry of 
      Public Health, Nonthaburi 11000, Thailand. k.srisawat@2015.ljmu.ac.uk.
FAU - Shepherd, Sam O
AU  - Shepherd SO
AD  - Research Institute for Sport and Exercise Sciences, Liverpool John Moores 
      University, Liverpool L3 3AF, UK. S.Shepherd@ljmu.ac.uk.
FAU - Lisboa, Paulo J
AU  - Lisboa PJ
AD  - Department of Applied Mathematics, Liverpool John Moores University, Liverpool L3 
      3AF, UK. P.J.Lisboa@ljmu.ac.uk.
FAU - Burniston, Jatin G
AU  - Burniston JG
AUID- ORCID: 0000-0001-7303-9318
AD  - Research Institute for Sport and Exercise Sciences, Liverpool John Moores 
      University, Liverpool L3 3AF, UK. j.burniston@ljmu.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171111
PL  - Switzerland
TA  - Proteomes
JT  - Proteomes
JID - 101621966
PMC - PMC5748565
OTO - NOTNLM
OT  - Preferred Reporting items for Systematic Review and Meta-analyses (PRISMA)
OT  - high intensity exercise
OT  - insulin resistance
OT  - mass spectrometry
OT  - meta-analysis (MA)
OT  - obese
OT  - protein abundance
OT  - systematic review (SR)
OT  - type 2 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2017/11/16 06:00
MHDA- 2017/11/16 06:01
PMCR- 2017/11/11
CRDT- 2017/11/16 06:00
PHST- 2017/09/29 00:00 [received]
PHST- 2017/11/02 00:00 [revised]
PHST- 2017/11/06 00:00 [accepted]
PHST- 2017/11/16 06:00 [entrez]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2017/11/16 06:01 [medline]
PHST- 2017/11/11 00:00 [pmc-release]
AID - proteomes5040030 [pii]
AID - proteomes-05-00030 [pii]
AID - 10.3390/proteomes5040030 [doi]
PST - epublish
SO  - Proteomes. 2017 Nov 11;5(4):30. doi: 10.3390/proteomes5040030.