PMID- 29137377
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220728
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 48
DP  - 2017 Oct 13
TI  - An evaluation of nutrition intervention during radiation therapy in patients with 
      locoregionally advanced nasopharyngeal carcinoma.
PG  - 83723-83733
LID - 10.18632/oncotarget.19381 [doi]
AB  - PURPOSE: To evaluate the effectiveness of nutrition intervention during radiation 
      for patients with locoregionally advanced (III-IVa) nasopharyngeal carcinoma 
      (NPC). MATERIALS AND METHODS: We retrospectively reviewed 117 patients with 
      locoregionally advanced (III-IVa) NPC treated between December 2015 and March 
      2016 in Zhejiang Cancer Hospital. All the patients underwent radical 
      chemo-radiotherapy. First, all the patients were divided into the nutrition 
      intervention group and the control group, depending on whether they accepted 
      nutrition intervention. Repeated measures were used to analyze the change of 
      nutritional indicators before, during, and after radiation therapy and to 
      simultaneously compare the difference in nutritional status between the two 
      groups at the same time point. Subsequently, the 117 patients were divided into 
      the malnourished group (weight loss > 5%) and the non-malnourished group (weight 
      loss </= 5%) according to whether their weight loss was over 5% of their body 
      weight during radiotherapy. Chi-square tests and logistic regression analysis 
      were used to explore the influence factors for the weight loss. RESULTS: The 
      repeated measures showed that all indicators including weight, body mass index 
      (BMI), albumin, pre-albumin(PA), and prognostic nutritional index (PNI) 
      dramatically declined in both groups compared with their levels before radiation 
      therapy (All p < 0.001). However, there was no significant difference between the 
      intervention and non-intervention groups regarding the mean values of nutritional 
      indicators at the same time point, that before, during, and after radiation 
      therapy, except BMI (All p > 0.05). Logistic regression analysis revealed grade >/= 
      3 radiation-induced oral mucositis as the prognostic factor for a poor nutrition 
      status (odds ratio, OR = 3.232, p = 0.021, confidence interval, CI [1.198, 
      8.820]). Besides this, patients with a decrease of >15% in pre-albumin level were 
      more likely to be malnourished (OR = 2.442, p = 0.041, CI [1.036, 5.757]). 
      Similar to that observed in our former analysis, we did not find that existing 
      nutrition intervention can significantly improve nutritional status (OR = 1.217, 
      p = 0.704, CI [0.042, 3.348]). CONCLUSIONS: Our study shows that the nutritional 
      status of the patients gradually declined during treatment. We concluded that 
      grade >/= 3 radiation-induced oral mucositis would aggravate the extent of 
      malnutrition during radiation therapy in patients with locoregionally advanced 
      NPC. Pre-albumin level was a predictive marker for weight loss in patients with 
      NPC. However, current nutrition intervention during radiation therapy can't 
      significantly reverse nutritional status.
FAU - Jin, Ting
AU  - Jin T
AD  - Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 
      310022, People's Republic of China.
AD  - Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang 310022, 
      People's Republic of China.
FAU - Li, Kai-Xin
AU  - Li KX
AD  - Department of Radiation Oncology, Quanzhou First Hospital Affiliated to Fujian 
      Medical University, Quanzhou, Fujian 362000, People's Republic of China.
FAU - Li, Pei-Jing
AU  - Li PJ
AD  - Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 
      310022, People's Republic of China.
AD  - Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang 310022, 
      People's Republic of China.
FAU - Huang, Shuang
AU  - Huang S
AD  - Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 
      310022, People's Republic of China.
AD  - Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang 310022, 
      People's Republic of China.
FAU - Chen, Xiao-Zhong
AU  - Chen XZ
AD  - Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 
      310022, People's Republic of China.
AD  - Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang 310022, 
      People's Republic of China.
FAU - Chen, Ming
AU  - Chen M
AD  - Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 
      310022, People's Republic of China.
AD  - Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang 310022, 
      People's Republic of China.
FAU - Hu, Qiao-Ying
AU  - Hu QY
AD  - Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 
      310022, People's Republic of China.
AD  - Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang 310022, 
      People's Republic of China.
FAU - Shi, Lei
AU  - Shi L
AD  - Department of Radiology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, 
      People's Republic of China.
AD  - Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang 310022, 
      People's Republic of China.
FAU - Chen, Yuan-Yuan
AU  - Chen YY
AD  - Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 
      310022, People's Republic of China.
AD  - Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang 310022, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20170719
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5663549
OTO - NOTNLM
OT  - nasopharyngeal carcinoma
OT  - nutrition intervention
OT  - radiotherapy
OT  - weight loss
COIS- CONFLICTS OF INTEREST None.
EDAT- 2017/11/16 06:00
MHDA- 2017/11/16 06:01
PMCR- 2017/10/13
CRDT- 2017/11/16 06:00
PHST- 2017/03/10 00:00 [received]
PHST- 2017/07/12 00:00 [accepted]
PHST- 2017/11/16 06:00 [entrez]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2017/11/16 06:01 [medline]
PHST- 2017/10/13 00:00 [pmc-release]
AID - 19381 [pii]
AID - 10.18632/oncotarget.19381 [doi]
PST - epublish
SO  - Oncotarget. 2017 Jul 19;8(48):83723-83733. doi: 10.18632/oncotarget.19381. 
      eCollection 2017 Oct 13.