PMID- 29137471
OWN - NLM
STAT- MEDLINE
DCOM- 20180906
LR  - 20220321
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Linking)
VI  - 67
IP  - 1
DP  - 2018 Mar 16
TI  - Serum levels of spexin and kisspeptin negatively correlate with obesity and 
      insulin resistance in women.
PG  - 45-56
AB  - Spexin (SPX) and kisspeptin (KISS) are novel peptides relevant in the context of 
      regulation of metabolism, food intake, puberty and reproduction. Here, we studied 
      changes of serum SPX and KISS levels in female non-obese volunteers (BMI<25 
      kg/m(2)) and obese patients (BMI>35 kg/m(2)). Correlations between SPX or KISS 
      with BMI, McAuley index, QUICKI, HOMA IR, serum levels of insulin, glucagon, 
      leptin, adiponectin, orexin-A, obestatin, ghrelin and GLP-1 were assessed. Obese 
      patients had lower SPX and KISS levels as compared to non-obese volunteers (SPX: 
      4.48+/-0.19 ng/ml vs. 6.63+/-0.29 ng/ml; p<0.001, KISS: 1.357+/-0.15 nmol/l vs. 
      2.165+/-0.174 nmol/l; p<0.01). SPX negatively correlated with BMI, HOMA-IR, 
      insulin, glucagon, active ghrelin and leptin. Positive correlations were found 
      between SPX and QUICKI index, McAuley index, serum levels of obestatin, GLP-1 and 
      adiponectin and orexin-A Serum KISS negatively correlated with BMI, HOMA-IR, 
      serum levels of insulin, glucagon, active ghrelin and leptin. KISS positively 
      correlated with QUICKI index, McAuley index and adiponectin. In summary, SPX and 
      KISS show negative correlations with obesity, insulin resistance indices, and 
      hormones known to affect insulin sensitivity in females. Both, SPX and KISS could 
      be therefore relevant in the pathophysiology of obesity and insulin resistance.
FAU - Kolodziejski, P A
AU  - Kolodziejski PA
AD  - Department of Animal Physiology and Biochemistry, Poznan University of Life 
      Sciences, Poznan, Poland. pawelbigi@o2.pl.
FAU - Pruszynska-Oszmalek, E
AU  - Pruszynska-Oszmalek E
FAU - Korek, E
AU  - Korek E
FAU - Sassek, M
AU  - Sassek M
FAU - Szczepankiewicz, D
AU  - Szczepankiewicz D
FAU - Kaczmarek, P
AU  - Kaczmarek P
FAU - Nogowski, L
AU  - Nogowski L
FAU - Mackowiak, P
AU  - Mackowiak P
FAU - Nowak, K W
AU  - Nowak KW
FAU - Krauss, H
AU  - Krauss H
FAU - Strowski, M Z
AU  - Strowski MZ
LA  - eng
PT  - Journal Article
DEP - 20171110
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Biomarkers)
RN  - 0 (KISS1 protein, human)
RN  - 0 (Kisspeptins)
RN  - 0 (Peptide Hormones)
RN  - 0 (SPX protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Kisspeptins/*blood
MH  - Middle Aged
MH  - Obesity/*blood/diagnosis
MH  - Peptide Hormones/*blood
EDAT- 2017/11/16 06:00
MHDA- 2018/09/07 06:00
CRDT- 2017/11/16 06:00
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2018/09/07 06:00 [medline]
PHST- 2017/11/16 06:00 [entrez]
AID - 933467 [pii]
AID - 10.33549/physiolres.933467 [doi]
PST - ppublish
SO  - Physiol Res. 2018 Mar 16;67(1):45-56. doi: 10.33549/physiolres.933467. Epub 2017 
      Nov 10.