PMID- 29137688
OWN - NLM
STAT- MEDLINE
DCOM- 20190116
LR  - 20210914
IS  - 1555-3906 (Electronic)
IS  - 0965-0407 (Print)
IS  - 0965-0407 (Linking)
VI  - 26
IP  - 3
DP  - 2018 Apr 10
TI  - The Long Noncoding RNA HOTAIR Promotes Colorectal Cancer Progression by Sponging 
      miR-197.
PG  - 473-481
LID - 10.3727/096504017X15105708598531 [doi]
AB  - The long noncoding RNA HOX transcript antisense RNA (HOTAIR) has been found to be 
      overexpressed in many human malignancies and involved in tumor progression and 
      metastasis. Although the downstream target through which HOTAIR modulates tumor 
      metastasis is not well known, evidence suggests that microRNA-197 (miR-197) might 
      be involved in this event. In the present study, the significance of HOTAIR and 
      miR-197 in the progression of colorectal cancer was detected in vitro and in 
      vivo. We found that HOTAIR expression was significantly increased in colorectal 
      cancer cells and tissues. In contrast, the expression of miR-197 was obviously 
      decreased. We further demonstrated that HOTAIR knockdown promoted apoptosis and 
      inhibited cell proliferation, migration, and invasion in vitro and in vivo. 
      Moreover, HOTAIR modulated the progression of colorectal cancer by competitively 
      binding miR-197. Taken together, our study has identified a novel pathway through 
      which HOTAIR exerts its oncogenic role and provided a molecular basis for 
      potential applications of HOTAIR in the prognosis and treatment of colorectal 
      cancer.
FAU - Lu, Xinyang
AU  - Lu X
AD  - Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical 
      UniversityJiningP.R. China.
FAU - Liu, Zhiqiang
AU  - Liu Z
AD  - Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical 
      UniversityJiningP.R. China.
FAU - Ning, Xiaofei
AU  - Ning X
AD  - Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical 
      UniversityJiningP.R. China.
FAU - Huang, Lunhua
AU  - Huang L
AD  - Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical 
      UniversityJiningP.R. China.
FAU - Jiang, Biao
AU  - Jiang B
AD  - Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical 
      UniversityJiningP.R. China.
LA  - eng
PT  - Journal Article
DEP - 20171114
PL  - United States
TA  - Oncol Res
JT  - Oncology research
JID - 9208097
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HOTAIR long untranslated RNA, human)
RN  - 0 (MIRN197 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Biomarkers, Tumor/genetics/*metabolism
MH  - Case-Control Studies
MH  - Cell Movement
MH  - *Cell Proliferation
MH  - Colorectal Neoplasms/genetics/metabolism/*pathology
MH  - Disease Progression
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - MicroRNAs/genetics/*metabolism
MH  - Prognosis
MH  - RNA, Long Noncoding/*genetics
MH  - Tumor Cells, Cultured
PMC - PMC7844719
EDAT- 2017/11/16 06:00
MHDA- 2019/01/17 06:00
PMCR- 2018/04/10
CRDT- 2017/11/16 06:00
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2019/01/17 06:00 [medline]
PHST- 2017/11/16 06:00 [entrez]
PHST- 2018/04/10 00:00 [pmc-release]
AID - OR1159 [pii]
AID - 10.3727/096504017X15105708598531 [doi]
PST - ppublish
SO  - Oncol Res. 2018 Apr 10;26(3):473-481. doi: 10.3727/096504017X15105708598531. Epub 
      2017 Nov 14.