PMID- 29138264
OWN - NLM
STAT- MEDLINE
DCOM- 20180718
LR  - 20181113
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 37
IP  - 6
DP  - 2017 Dec 22
TI  - Comprehensive investigation of cytokine- and immune-related gene variants in 
      HBV-associated hepatocellular carcinoma patients.
LID - BSR20171263 [pii]
LID - 10.1042/BSR20171263 [doi]
AB  - Host genotype may be closely related to the different outcomes of Hepatitis B 
      virus (HBV) infection. To identify the association of variants and HBV infection, 
      we comprehensively investigated the cytokine- and immune-related gene mutations 
      in patients with HBV associated hepatocellular carcinoma (HBV-HCC). Fifty-three 
      HBV-HCC patients, 53 self-healing cases (SH) with HBV infection history and 53 
      healthy controls (HCs) were recruited, the whole exon region of 404 genes were 
      sequenced at >900x depth. Comprehensive variants and gene levels were compared 
      between HCC and HC, and HCC and SH. Thirty-nine variants (adjusted P<0.0001, 
      Fisher's exact test) and 11 genes (adjusted P<0.0001, optimal unified approach 
      for rare variant association test (SKAT-O) gene level test) were strongly 
      associated with HBV-HCC. Thirty-four variants were from eight human leukocyte 
      antigen (HLA) genes that were previously reported to be associated with HBV-HCC. 
      The novelties of our study are: five variants (rs579876, rs579877, rs368692979, 
      NM_145007:c.*131_*130delTG, NM_139165:exon5:c.623-2->TT) from three genes 
      (REAT1E, NOD-like receptor (NLR) protein 11 (NLRP11), hydroxy-carboxylic acid 
      receptor 2 (HCAR2)) were found strongly associated with HBV-HCC. We found 39 
      different variants in 11 genes that were significantly related to HBV-HCC. Five 
      of them were new findings. Our data implied that chronic hepatitis B patients who 
      carry these variants are at a high risk of developing HCC.
CI  - (c) 2017 The Author(s).
FAU - Yu, Fengxue
AU  - Yu F
AD  - Department of Science and Technology, The Hebei Key Laboratory of 
      Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, 
      China fengxue2002yu202356@hotmail.com.
FAU - Zhang, Xiaolin
AU  - Zhang X
AD  - Division of Epidemiology, School of Public Health, Hebei Medical University, 
      Shijiazhuang, China.
FAU - Tian, Suzhai
AU  - Tian S
AD  - Department of Science and Technology, The Hebei Key Laboratory of 
      Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, 
      China.
FAU - Geng, Lianxia
AU  - Geng L
AD  - Department of Science and Technology, The Hebei Key Laboratory of 
      Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, 
      China.
FAU - Xu, Weili
AU  - Xu W
AD  - Department of Pediatric Surgery, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, China.
FAU - Ma, Ning
AU  - Ma N
AD  - Division of Epidemiology, School of Public Health, Hebei Medical University, 
      Shijiazhuang, China.
FAU - Wang, Mingbang
AU  - Wang M
AD  - Department of Central Laboratory, Shenzhen Following Precision Medical Research 
      Institute, Shenzhen, Guangdong, China.
FAU - Jia, Yuan
AU  - Jia Y
AD  - Department of Infectious Disease Control, The Second Hospital of Hebei Medical 
      University, Shijiazhuang, China.
FAU - Liu, Xuechen
AU  - Liu X
AD  - Department of Gastroenterology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, China.
FAU - Ma, Junji
AU  - Ma J
AD  - Department of Gastroenterology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, China.
FAU - Quan, Yuan
AU  - Quan Y
AD  - Department of Infectious Disease, Hebei Chest Hospital, Shijiazhuang, China.
FAU - Zhang, Chaojun
AU  - Zhang C
AD  - Department of Central Laboratory, The Second Hospital of Hebei Medical 
      University, Shijiazhuang, China.
FAU - Guo, Lina
AU  - Guo L
AD  - Department of Central Laboratory, The Second Hospital of Hebei Medical 
      University, Shijiazhuang, China.
FAU - An, Wenting
AU  - An W
AD  - Department of Central Laboratory, The Second Hospital of Hebei Medical 
      University, Shijiazhuang, China.
FAU - Liu, Dianwu
AU  - Liu D
AD  - Division of Epidemiology, School of Public Health, Hebei Medical University, 
      Shijiazhuang, China.
LA  - eng
PT  - Journal Article
DEP - 20171212
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Carcinoma, Hepatocellular/etiology/*genetics/virology
MH  - Case-Control Studies
MH  - Cytokines/*genetics
MH  - Exons/genetics
MH  - Female
MH  - Genotype
MH  - Hepatitis B virus/pathogenicity
MH  - Hepatitis B, Chronic/complications/genetics
MH  - Humans
MH  - Liver Neoplasms/*genetics/virology
MH  - Male
MH  - Middle Aged
MH  - Mutation/*genetics
PMC - PMC5725607
OTO - NOTNLM
OT  - HBV-HCC
OT  - Target Region Sequencing (TRS)
OT  - cytokine
OT  - gene level association
OT  - immune genes
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2017/11/16 06:00
MHDA- 2018/07/19 06:00
PMCR- 2017/12/12
CRDT- 2017/11/16 06:00
PHST- 2017/09/15 00:00 [received]
PHST- 2017/11/08 00:00 [revised]
PHST- 2017/11/13 00:00 [accepted]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2018/07/19 06:00 [medline]
PHST- 2017/11/16 06:00 [entrez]
PHST- 2017/12/12 00:00 [pmc-release]
AID - BSR20171263 [pii]
AID - 10.1042/BSR20171263 [doi]
PST - epublish
SO  - Biosci Rep. 2017 Dec 12;37(6):BSR20171263. doi: 10.1042/BSR20171263. Print 2017 
      Dec 22.