PMID- 29138698
OWN - NLM
STAT- MEDLINE
DCOM- 20180713
LR  - 20181202
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2017
DP  - 2017
TI  - Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic 
      Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the 
      Hippocampus.
PG  - 3467805
LID - 10.1155/2017/3467805 [doi]
LID - 3467805
AB  - Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid and 
      metabolized by soluble epoxide hydrolase (sEH). The role of EETs in synaptic 
      function in the central nervous system is still largely unknown. We found that 
      pharmacological inhibition of sEH to stabilize endogenous EETs and exogenous 
      14,15-EET significantly increased the field excitatory postsynaptic potential 
      (fEPSP) response in the CA1 area of the hippocampus, while additionally enhancing 
      high-frequency stimulation- (HFS-) induced long-term potentiation (LTP) and 
      forskolin- (FSK-) induced LTP. sEH inhibitor (sEHI) 
      N-[1-(oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy) phenyl)-urea (TPPU) and 
      exogenous 14,15-EET increased HFS-LTP, which could be blocked by an 
      N-methyl-D-aspartate (NMDA) receptor subunit NR2B antagonist. TPPU- or 
      14,15-EET-facilitated FSK-mediated LTP can be potentiated by an A1 adenosine 
      receptor antagonist and a phosphodiesterase inhibitor, but is prevented by a 
      cAMP-dependent protein kinase (PKA) inhibitor. sEHI and 14,15-EET upregulated the 
      activation of extracellular signal-regulated kinases (ERKs) and Ca2+/calmodulin- 
      (CaM-) dependent protein kinase II (CaMKII). Phosphorylation of synaptic 
      receptors NR2B and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) 
      receptor subunit GluR1 was increased by TPPU and 14,15-EET administration. These 
      results indicated that EETs increased NMDAR- and FSK-mediated synaptic 
      potentiation via the AC-cAMP-PKA signaling cascade and upregulated the ERKs and 
      CaMKII, resulting in increased phosphorylation of NR2B and GluR1 in the 
      hippocampus.
FAU - Wu, Han-Fang
AU  - Wu HF
AD  - Department and Institute of Physiology, School of Medicine, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Chen, Yi-Ju
AU  - Chen YJ
AD  - Department and Institute of Physiology, School of Medicine, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Wu, Su-Zhen
AU  - Wu SZ
AD  - Department of Anesthesiology, Chi-Mei Medical Center, Tainan, Taiwan.
FAU - Lee, Chi-Wei
AU  - Lee CW
AD  - Department and Institute of Physiology, School of Medicine, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Chen, I-Tuan
AU  - Chen IT
AD  - Department and Institute of Physiology, School of Medicine, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Lee, Yi-Chao
AU  - Lee YC
AD  - Graduate Institute of Neural Regenerative Medicine, College of Medical Science 
      and Technology, Taipei Medical University, Taipei, Taiwan.
FAU - Huang, Chi-Chen
AU  - Huang CC
AD  - Graduate Institute of Neural Regenerative Medicine, College of Medical Science 
      and Technology, Taipei Medical University, Taipei, Taiwan.
FAU - Hsing, Chung-Hsi
AU  - Hsing CH
AUID- ORCID: 0000-0002-6091-5371
AD  - Department of Anesthesiology, Chi-Mei Medical Center, Tainan, Taiwan.
FAU - Tang, Chih-Wei
AU  - Tang CW
AD  - Department of Neurology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
AD  - Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
FAU - Lin, Hui-Ching
AU  - Lin HC
AUID- ORCID: 0000-0002-1639-9293
AD  - Department and Institute of Physiology, School of Medicine, National Yang-Ming 
      University, Taipei, Taiwan.
AD  - Graduate Institute of Neural Regenerative Medicine, College of Medical Science 
      and Technology, Taipei Medical University, Taipei, Taiwan.
AD  - Brain Research Center, National Yang-Ming University, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20170824
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 81276-03-1 (14,15-epoxy-5,8,11-eicosatrienoic acid)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 3.3.2.- (Epoxide Hydrolases)
RN  - EC 3.3.2.10 (Ephx2 protein, mouse)
RN  - FC398RK06S (8,11,14-Eicosatrienoic Acid)
SB  - IM
MH  - 8,11,14-Eicosatrienoic Acid/administration & dosage/*analogs & derivatives
MH  - Animals
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
MH  - Cyclic AMP/*metabolism
MH  - Epoxide Hydrolases/antagonists & inhibitors/*metabolism
MH  - Hippocampus/drug effects/*metabolism
MH  - *Long-Term Potentiation/drug effects
MH  - Mice, Inbred C57BL
MH  - Neurons/drug effects/metabolism
MH  - Receptors, AMPA/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism
MH  - Signal Transduction
PMC - PMC5613711
EDAT- 2017/11/16 06:00
MHDA- 2018/07/14 06:00
PMCR- 2017/08/24
CRDT- 2017/11/16 06:00
PHST- 2017/03/17 00:00 [received]
PHST- 2017/07/03 00:00 [revised]
PHST- 2017/07/27 00:00 [accepted]
PHST- 2017/11/16 06:00 [entrez]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2018/07/14 06:00 [medline]
PHST- 2017/08/24 00:00 [pmc-release]
AID - 10.1155/2017/3467805 [doi]
PST - ppublish
SO  - Neural Plast. 2017;2017:3467805. doi: 10.1155/2017/3467805. Epub 2017 Aug 24.