PMID- 29138743
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2226-4485 (Print)
IS  - 2218-6050 (Electronic)
IS  - 2218-6050 (Linking)
VI  - 7
IP  - 4
DP  - 2017
TI  - Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological 
      features and immunohistochemical results.
PG  - 294-299
LID - 10.4314/ovj.v7i4.1 [doi]
AB  - This report documents a case of secondary inappropriate erythrocytosis in a cat 
      with renal cell adenocarcinoma, its stabilization through manual 
      erythrocytapheresis, and the EPO-immunostaining on the affected kidney. An 
      11-year-old cat was presented with lethargy, weight loss and polyuria/polydipsia. 
      An abdominal mass was detected upon physical examination. Clinicopathological 
      work-up revealed marked erythrocytosis (HCT value 64.8%), renal azotemia and 
      decreased urine specific gravity (USG). An abdominal ultrasound was performed, 
      localizing the mass in the right kidney. Serum erythropoietin (EPO) was above the 
      reference interval (RI), and the cytology of the mass was indicative of renal 
      carcinoma. Manual erythrocytapheresis was performed in order to stabilize the 
      patient before surgery, improving the cat's clinical and clinicopathological 
      condition. After nephrectomy, EPO and creatinine concentrations returned within 
      the RI, while the USG markedly increased. Histopathology confirmed the diagnosis 
      of renal adenocarcinoma. Immunohistochemistry with anti-EPO antibody revealed 
      diffuse and strong cytoplasmatic positivity in tumor cells.
FAU - Troia, Roberta
AU  - Troia R
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of 
      Bologna, Italy.
FAU - Agnoli, Chiara
AU  - Agnoli C
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of 
      Bologna, Italy.
FAU - Fracassi, Federico
AU  - Fracassi F
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of 
      Bologna, Italy.
FAU - Bettini, Giuliano
AU  - Bettini G
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of 
      Bologna, Italy.
FAU - Sfacteria, Alessandra
AU  - Sfacteria A
AD  - Department of Veterinary Sciences, University of Messina, Italy.
FAU - Pisoni, Luciano
AU  - Pisoni L
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of 
      Bologna, Italy.
FAU - Dondi, Francesco
AU  - Dondi F
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of 
      Bologna, Italy.
LA  - eng
PT  - Case Reports
DEP - 20171019
PL  - Libya
TA  - Open Vet J
JT  - Open veterinary journal
JID - 101653182
PMC - PMC5681726
OTO - NOTNLM
OT  - Erythropoietin
OT  - Feline
OT  - Immunohistochemistry
OT  - Manual erythrocytapheresis
OT  - Renal neoplasia
EDAT- 2017/11/16 06:00
MHDA- 2017/11/16 06:01
PMCR- 2017/01/01
CRDT- 2017/11/16 06:00
PHST- 2017/03/05 00:00 [received]
PHST- 2017/10/06 00:00 [accepted]
PHST- 2017/11/16 06:00 [entrez]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2017/11/16 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - OpenVetJ-7-294 [pii]
AID - 10.4314/ovj.v7i4.1 [doi]
PST - ppublish
SO  - Open Vet J. 2017;7(4):294-299. doi: 10.4314/ovj.v7i4.1. Epub 2017 Oct 19.