PMID- 29138914
OWN - NLM
STAT- MEDLINE
DCOM- 20180911
LR  - 20181202
IS  - 1432-2323 (Electronic)
IS  - 0364-2313 (Linking)
VI  - 42
IP  - 6
DP  - 2018 Jun
TI  - Impact of "Tailored" Parathyroidectomy for Treatment of Primary 
      Hyperparathyroidism in Patients with Multiple Endocrine Neoplasia Type 1.
PG  - 1772-1778
LID - 10.1007/s00268-017-4366-z [doi]
AB  - BACKGROUND: Whether total parathyroidectomy (TPTX) or subtotal parathyroidectomy 
      (SPTX) should be performed for primary hyperparathyroidism (PHPT) in patients 
      with multiple endocrine neoplasia type 1 (MEN1) is controversial. At our 
      institution, the parathyroidectomy strategy is based on the number of enlarged 
      intraoperative parathyroid glands. We retrospectively analyzed our 
      parathyroidectomy procedures. METHODS: Data of PHPT treatment in patients with 
      MEN1 who underwent parathyroidectomy from 1982 to 2012 at our department were 
      retrospectively collected. The data were grouped according to the surgical 
      procedure: TPTX, SPTX, and less than SPTX (LPTX). TPTX or SPTX was selected based 
      on the preoperative examination findings and number of enlarged intraoperative 
      parathyroid glands. The outcomes were the disease-free survival (DFS) rate and 
      postoperative calcium replacement rate based on Kaplan-Meier analysis for each 
      type of surgical procedure. RESULTS: Forty-five patients were analyzed. The 
      overall 5- and 10-year DFS was 91.7 and 55.8%, respectively. The 5- and 10-year 
      DFS in each subgroup was 100.0 and 85.7% in the TPTX group, 89.4 and 57.3% in the 
      SPTX group, and 91.6 and 57.3% in the LPTX group, respectively. The postoperative 
      calcium replacement rate at 1 and 12 months was 91.7 and 58.3% in the TPTX group, 
      21.1 and 7.0% in the SPTX group, and 30.0 and 0.0% in the LPTX group, 
      respectively. CONCLUSIONS: Although LPTX was not satisfactory as a standard 
      procedure, both SPTX and TPTX are effective treatment methods for PHPT in 
      patients with MEN1. The parathyroidectomy strategy should be based on 
      intraoperative evaluation of the parathyroid glands.
FAU - Horiuchi, Kiyomi
AU  - Horiuchi K
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 
      Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan. horiuchi.kiyomi@twmu.ac.jp.
FAU - Sakurai, Momoko
AU  - Sakurai M
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 
      Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Haniu, Kento
AU  - Haniu K
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 
      Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Nagai, Erin
AU  - Nagai E
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 
      Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Tokumitsu, Hiroki
AU  - Tokumitsu H
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 
      Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Yoshida, Yusaku
AU  - Yoshida Y
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 
      Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Omi, Yoko
AU  - Omi Y
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 
      Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Sakamoto, Akiko
AU  - Sakamoto A
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 
      Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Okamoto, Takahiro
AU  - Okamoto T
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 
      Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism, Primary/mortality/*surgery
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*surgery
MH  - Parathyroidectomy/*methods
MH  - Retrospective Studies
EDAT- 2017/11/16 06:00
MHDA- 2018/09/12 06:00
CRDT- 2017/11/16 06:00
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2018/09/12 06:00 [medline]
PHST- 2017/11/16 06:00 [entrez]
AID - 10.1007/s00268-017-4366-z [pii]
AID - 10.1007/s00268-017-4366-z [doi]
PST - ppublish
SO  - World J Surg. 2018 Jun;42(6):1772-1778. doi: 10.1007/s00268-017-4366-z.