PMID- 29139072
OWN - NLM
STAT- MEDLINE
DCOM- 20181108
LR  - 20200306
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Print)
IS  - 0944-1344 (Linking)
VI  - 25
IP  - 3
DP  - 2018 Jan
TI  - Elimination and detoxification of 2,4-D by Umbelopsis isabellina with the 
      involvement of cytochrome P450.
PG  - 2738-2743
LID - 10.1007/s11356-017-0571-4 [doi]
AB  - The chemical 2,4-dichlorophenoxyacetic acid (2,4-D) is used in agriculture as a 
      herbicide. Its intensive use has an adverse effect on the environment. This study 
      involved examining the degradation of 2,4-D compound by the filamentous fungus 
      Umbelopsis isabellina. After 5 days of incubation, 98% of the herbicide (added at 
      25 mg L(-1)) was found to be removed. The elimination of 2,4-D by U. isabellina 
      was connected with the formation of 2,4-dichlorophenol (2,4-DCP), which resulted 
      in a 60% decrease in the sample toxicity toward Artemia franciscana larvae. The 
      metabolism of 2,4-D was inhibited by the addition of metyrapone, a known 
      cytochrome P450 inhibitor. It provides evidence that cytochrome P450 system is 
      involved in 2,4-D metabolism in U. isabellina.
FAU - Nykiel-Szymanska, Justyna
AU  - Nykiel-Szymanska J
AD  - Department of Industrial Microbiology and Biotechnology, Faculty of Biology and 
      Environmental Protection, University of Lodz, Banacha Street 12/16, 90-237, Lodz, 
      Poland.
FAU - Stolarek, Paulina
AU  - Stolarek P
AD  - Department of Industrial Microbiology and Biotechnology, Faculty of Biology and 
      Environmental Protection, University of Lodz, Banacha Street 12/16, 90-237, Lodz, 
      Poland.
FAU - Bernat, Przemyslaw
AU  - Bernat P
AUID- ORCID: 0000-0002-5589-1555
AD  - Department of Industrial Microbiology and Biotechnology, Faculty of Biology and 
      Environmental Protection, University of Lodz, Banacha Street 12/16, 90-237, Lodz, 
      Poland. przemyslaw.bernat@biol.uni.lodz.pl.
LA  - eng
GR  - 2015/19/B/NZ9/00167/Narodowe Centrum Nauki/
PT  - Journal Article
DEP - 20171114
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Herbicides)
RN  - 0 (Soil Pollutants)
RN  - 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
SB  - IM
MH  - 2,4-Dichlorophenoxyacetic Acid/*analysis/metabolism
MH  - Biodegradation, Environmental
MH  - Cytochrome P-450 Enzyme System/*metabolism
MH  - Fungi/enzymology/*metabolism
MH  - Herbicides/*analysis/metabolism
MH  - Inactivation, Metabolic
MH  - Models, Theoretical
MH  - Oxidation-Reduction
MH  - Soil Pollutants/*analysis/metabolism
PMC - PMC5773638
OTO - NOTNLM
OT  - 2,4-D metabolites
OT  - 2,4-dichlorophenoxyacetic acid
OT  - Artemia franciscana
OT  - Degradation
OT  - Toxicity
COIS- The authors declare that they have no conflict of interest.
EDAT- 2017/11/16 06:00
MHDA- 2018/11/09 06:00
PMCR- 2017/11/14
CRDT- 2017/11/16 06:00
PHST- 2017/05/07 00:00 [received]
PHST- 2017/10/24 00:00 [accepted]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2018/11/09 06:00 [medline]
PHST- 2017/11/16 06:00 [entrez]
PHST- 2017/11/14 00:00 [pmc-release]
AID - 10.1007/s11356-017-0571-4 [pii]
AID - 571 [pii]
AID - 10.1007/s11356-017-0571-4 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2018 Jan;25(3):2738-2743. doi: 
      10.1007/s11356-017-0571-4. Epub 2017 Nov 14.