PMID- 29139086
OWN - NLM
STAT- MEDLINE
DCOM- 20180927
LR  - 20181114
IS  - 1936-0568 (Electronic)
IS  - 1936-055X (Print)
IS  - 1936-055X (Linking)
VI  - 12
IP  - 2
DP  - 2018 Jun
TI  - Diagnostic Approaches for Salivary Gland Tumors with Secretory and Microcystic 
      Features.
PG  - 237-243
LID - 10.1007/s12105-017-0864-4 [doi]
AB  - Secretory carcinoma (SC) of the salivary gland is a new entity that shares the 
      unique morphologic features and cytogenetic characteristics of the ETV6-NTRK3 
      fusion gene with its breast counterpart. Before identification of SC of the 
      salivary gland, it was most frequently diagnosed as acinic cell carcinoma 
      (AciCC). We retrospectively reviewed our own database of salivary gland tumors 
      harboring microcystic and papillary architecture and/or secretory features that 
      were originally diagnosed as AciCC. We selected nine cases of AciCC showing 
      diffuse S-100 expression on immunohistochemistry (IHC). A recently diagnosed case 
      of SC was included in the study as a reference sample. We performed IHC of S-100 
      and mammaglobin and ETV6 gene fluorescence in situ hybridization (FISH) in all 
      cases. Seven cases were positive for both S-100 and mammaglobin, while five of 
      the seven (71.4%) demonstrated ETV6 gene translocation by FISH. In the cases 
      which did not co-express either S-100 or mammaglobin on IHC, ETV6 gene 
      rearrangement was not shown on FISH. In conclusion, if a salivary gland tumor has 
      morphologic features of SC with co-expression of S-100 and mammaglobin, ETV6 FISH 
      can be performed to confirm the diagnosis of SC of the salivary gland.
FAU - Woo, Ha Young
AU  - Woo HY
AD  - Department of Pathology, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, Seoul, 120-752, Republic of Korea.
FAU - Choi, Eun Chang
AU  - Choi EC
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, 50 
      Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
FAU - Yoon, Sun Och
AU  - Yoon SO
AD  - Department of Pathology, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, Seoul, 120-752, Republic of Korea. soyoon@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20171114
PL  - United States
TA  - Head Neck Pathol
JT  - Head and neck pathology
JID - 101304010
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (ETV6-NTRK3 fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/analysis
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Oncogene Proteins, Fusion/genetics
MH  - Retrospective Studies
MH  - Salivary Gland Neoplasms/*diagnosis/genetics/pathology
MH  - Young Adult
PMC - PMC5953885
OTO - NOTNLM
OT  - ETV6-NTRK3
OT  - Mammaglobin
OT  - S-100
OT  - Salivary gland tumor
OT  - Secretory carcinoma
COIS- CONFLICT OF INTEREST: The authors have no conflicts of interest or funding to 
      disclose. RESEARCH INVOLVING HUMAN AND ANIMAL RIGHTS: This article does not 
      contain any studies with human participants or animals performed by any of the 
      authors.
EDAT- 2017/11/16 06:00
MHDA- 2018/09/28 06:00
PMCR- 2018/11/14
CRDT- 2017/11/16 06:00
PHST- 2017/08/02 00:00 [received]
PHST- 2017/11/06 00:00 [accepted]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2018/09/28 06:00 [medline]
PHST- 2017/11/16 06:00 [entrez]
PHST- 2018/11/14 00:00 [pmc-release]
AID - 10.1007/s12105-017-0864-4 [pii]
AID - 864 [pii]
AID - 10.1007/s12105-017-0864-4 [doi]
PST - ppublish
SO  - Head Neck Pathol. 2018 Jun;12(2):237-243. doi: 10.1007/s12105-017-0864-4. Epub 
      2017 Nov 14.