PMID- 29139195
OWN - NLM
STAT- MEDLINE
DCOM- 20181031
LR  - 20210109
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 23
IP  - 5
DP  - 2018 May
TI  - Phenotypic characteristics associated with slow gait speed in idiopathic 
      pulmonary fibrosis.
PG  - 498-506
LID - 10.1111/resp.13213 [doi]
AB  - BACKGROUND AND OBJECTIVE: Usual gait speed over 4 m (4MGS) is an established 
      functional performance measure in older adults that consistently predicts adverse 
      health outcomes, but few data exist in idiopathic pulmonary fibrosis (IPF). We 
      assessed the reliability of 4MGS, its relationship with established outcome 
      measures and its responsiveness to pulmonary rehabilitation. METHODS: In four 
      prospective IPF cohorts, 4MGS inter-observer (n = 46) and test-retest (n = 46) 
      reliability, concurrent validity (n = 65 and n = 62) and responsiveness (n = 60) 
      were determined. The phenotypic characteristics of all patients stratified 
      according to slow 4MGS (<0.8 m/s) were compared, including lung function 
      parameters, HRCT of the chest, 6-min walking distance (6MWD), Medical Respiratory 
      Council (MRC) dyspnoea score, King's Brief Interstitial Lung Disease (KBILD) 
      questionnaire and Gender, Age and lung Physiology (GAP) prognostic index. 
      RESULTS: Intra-class correlation coefficients for inter-observer and test-retest 
      reliability were 0.996 and 0.983, respectively. There was a strong association 
      between 4MGS and 6MWD (r = 0.76; P < 0.0001) and moderate correlations with MRC 
      (r = -0.56), KBILD (r = 0.44) and GAP index (r = -0.41); all P < 0.005. 4MGS 
      improved significantly with pulmonary rehabilitation (mean (95% CI) change: 0.16 
      (0.12-0.20) m/s), effect size 0.65. Patients with slow 4MGS had significantly 
      worse exercise performance (6MWD: -167 (-220 to -133) m), dyspnoea, health status 
      and prognosis index than those with preserved 4MGS, despite similar lung function 
      and HRCT parameters. CONCLUSION: 4MGS is a simple, reliable, valid and responsive 
      tool that may detect a patient phenotype with worse exercise performance, 
      dyspnoea, health status and prognosis index in stable IPF.
CI  - (c) 2017 Asian Pacific Society of Respirology.
FAU - Nolan, Claire M
AU  - Nolan CM
AUID- ORCID: 0000-0001-9067-599X
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Group, Royal Brompton and 
      Harefield NHS Foundation Trust, London, UK.
AD  - National Heart and Lung Institute, Imperial College London, London, UK.
FAU - Maddocks, Matthew
AU  - Maddocks M
AUID- ORCID: 0000-0002-0189-0952
AD  - Division of Palliative Care, Policy and Rehabilitation, King's College London, 
      Cicely Saunders Institute, London, UK.
FAU - Maher, Toby M
AU  - Maher TM
AD  - Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Foundation 
      Trust, London, UK.
AD  - Fibrosis Research Group, National Heart and Lung Institute, Imperial College 
      London, London, UK.
FAU - Canavan, Jane L
AU  - Canavan JL
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Group, Royal Brompton and 
      Harefield NHS Foundation Trust, London, UK.
FAU - Jones, Sarah E
AU  - Jones SE
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Group, Royal Brompton and 
      Harefield NHS Foundation Trust, London, UK.
AD  - National Heart and Lung Institute, Imperial College London, London, UK.
FAU - Barker, Ruth E
AU  - Barker RE
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Group, Royal Brompton and 
      Harefield NHS Foundation Trust, London, UK.
FAU - Patel, Suhani
AU  - Patel S
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Group, Royal Brompton and 
      Harefield NHS Foundation Trust, London, UK.
FAU - Jacob, Joseph
AU  - Jacob J
AD  - Fibrosis Research Group, National Heart and Lung Institute, Imperial College 
      London, London, UK.
FAU - Cullinan, Paul
AU  - Cullinan P
AD  - Department of Occupational and Environmental Medicine, Imperial College London, 
      London, UK.
FAU - Man, William D-C
AU  - Man WD
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Group, Royal Brompton and 
      Harefield NHS Foundation Trust, London, UK.
AD  - National Heart and Lung Institute, Imperial College London, London, UK.
LA  - eng
GR  - CTF-01-12-04/DH_/Department of Health/United Kingdom
GR  - DHCS/07/07/009/DH_/Department of Health/United Kingdom
GR  - G1002113/MRC_/Medical Research Council/United Kingdom
GR  - PB-PG-0213-30003/DH_/Department of Health/United Kingdom
GR  - DRF-2014-07-089/DH_/Department of Health/United Kingdom
GR  - CDF-2017-10-009/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171114
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Dyspnea/*etiology/physiopathology
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/diagnostic imaging/*physiopathology/rehabilitation
MH  - Male
MH  - Observer Variation
MH  - Outcome Assessment, Health Care
MH  - Phenotype
MH  - Prognosis
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Respiratory Function Tests
MH  - Surveys and Questionnaires
MH  - Walk Test
MH  - *Walking Speed
OTO - NOTNLM
OT  - gait
OT  - idiopathic pulmonary fibrosis
OT  - outcome assessment
OT  - phenotype
OT  - walking speed
EDAT- 2017/11/16 06:00
MHDA- 2018/11/01 06:00
CRDT- 2017/11/16 06:00
PHST- 2017/04/27 00:00 [received]
PHST- 2017/09/18 00:00 [revised]
PHST- 2017/10/09 00:00 [accepted]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2018/11/01 06:00 [medline]
PHST- 2017/11/16 06:00 [entrez]
AID - 10.1111/resp.13213 [doi]
PST - ppublish
SO  - Respirology. 2018 May;23(5):498-506. doi: 10.1111/resp.13213. Epub 2017 Nov 14.