PMID- 29139550
OWN - NLM
STAT- MEDLINE
DCOM- 20181226
LR  - 20181226
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 41
IP  - 1
DP  - 2018 Jan
TI  - Long-term clinical and echocardiographic outcomes of Mitraclip therapy in 
      patients nonresponders to cardiac resynchronization.
PG  - 65-72
LID - 10.1111/pace.13241 [doi]
AB  - OBJECTIVES: This study deals with clinical and echocardiographic outcomes in 
      cardiac resynchronization therapy (CRT) nonresponders patients undergoing 
      Mitraclip procedure. BACKGROUND: Functional mitral regurgitation (FMR) occurs in 
      approximately one-third of heart failure (HF) patients. Resynchronization therapy 
      may correct FMR in patients with HF; however, significant FMR persists in 20-25% 
      of CRT patients. METHODS: All patients included were previously treated with CRT 
      for at least 6 months and remained classified as New York Heart Association 
      (NYHA) functional class III or IV despite optimal medical therapy; the 
      echocardiographic assessment showed lack of decrease of the left ventricular 
      end-systolic volume (LVESV) of at least 10% and residual moderate-to-severe or 
      severe FMR. Clinical and echocardiographic follow-up was scheduled at 1, 3, 6, 
      and 12 months after Mitraclip implantation, and every 6 months thereafter. 
      RESULTS: Thirty patients fulfilled inclusion criteria. Before Mitraclip 
      implantation NYHA class was III in 83% and IV in 17% of patients; after CRT no 
      patient experienced an improvement in FMR. There was a significant improvement in 
      NYHA class from baseline to 6 months, which remained sustained at 12 and 24 
      months. The degree of FMR significantly improved from baseline to 6 months and 
      from 6 to 12 months. There was left ventricle remodeling with significant 
      reduction of LVESV and an increase of left ventricle ejection fraction at 6 and 
      12 months, while the opposite trend was noted between 12 and 24 months 
      CONCLUSION: Treatment of moderate to severe FMR in CRT nonresponder is feasible, 
      safe, and reasonably effective in reducing cardiac symptoms.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Giaimo, Valerio L
AU  - Giaimo VL
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Zappulla, Paolo
AU  - Zappulla P
AUID- ORCID: 0000-0001-5014-5353
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Cirasa, Arianna
AU  - Cirasa A
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Tempio, Donatella
AU  - Tempio D
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Sanfilippo, Maria
AU  - Sanfilippo M
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Rapisarda, Giulia
AU  - Rapisarda G
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Trovato, Danilo
AU  - Trovato D
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Grazia, Angelo Di
AU  - Grazia AD
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Liotta, Claudio
AU  - Liotta C
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Grasso, Carmelo
AU  - Grasso C
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Capodanno, Davide
AU  - Capodanno D
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Tamburino, Corrado
AU  - Tamburino C
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
FAU - Calvi, Valeria
AU  - Calvi V
AD  - Arrhythmology OU, Ferrarotto Hospital, University of Catania, Catania, Italy.
LA  - eng
PT  - Journal Article
DEP - 20180109
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Aged
MH  - *Cardiac Resynchronization Therapy
MH  - Cardiac Surgical Procedures/*instrumentation
MH  - Echocardiography
MH  - Female
MH  - Heart Failure/diagnostic imaging/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Mitral Valve Insufficiency/diagnostic imaging/physiopathology/*therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Mitraclip
OT  - cardiac resynchronization therapy
OT  - functional mitral regurgitation
OT  - heart failure
EDAT- 2017/11/16 06:00
MHDA- 2018/12/27 06:00
CRDT- 2017/11/16 06:00
PHST- 2017/01/06 00:00 [received]
PHST- 2017/10/18 00:00 [revised]
PHST- 2017/11/04 00:00 [accepted]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2018/12/27 06:00 [medline]
PHST- 2017/11/16 06:00 [entrez]
AID - 10.1111/pace.13241 [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2018 Jan;41(1):65-72. doi: 10.1111/pace.13241. Epub 
      2018 Jan 9.