PMID- 29140729
OWN - NLM
STAT- MEDLINE
DCOM- 20180627
LR  - 20181202
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 40
IP  - 2
DP  - 2018
TI  - Gene expression and gene associations during the development of heart failure 
      with preserved ejection fraction in the Dahl salt sensitive model of 
      hypertension.
PG  - 155-166
LID - 10.1080/10641963.2017.1346113 [doi]
AB  - Gene expression and associations were examined in a model of heart failure with 
      preserved ejection fraction (HFpEF), a condition with minimal effective 
      treatment. Genes with at least two studies showing significant changes in Dahl 
      rat with heart failure were examined by meta-analysis. Significantly increased in 
      expression were iNOS, p47phox, ADM, ANP, OPN, ACE, MCP-1, GP91PHOX, ICAM-1, 
      TGF-beta1, CTGF, ET-1, p22phox, ETB, BNP, ETA, MMP13, Col1a1, MMP2, TIMP1, Col3a1, 
      Il-1beta, beta-MHC, ECE1, MMP14, AGT, and MMP9. In contrast, GLUT4, VEGF, eNOS, HIF-1alpha, 
      and PGC1-alpha were significantly decreased in expression. The top biological process 
      clusters identified in Database for Annotation, Visualization and Integrated 
      Discovery, ToppGene, and PANTHER were collagen metabolic process, cellular ion 
      homeostasis, regulation of cell migration, and response to decreased oxygen 
      levels. These data suggest refocusing understanding of the pathophysiology of 
      HFpEF to pathways involved in collagen metabolism, cell migration likely for 
      inflammatory cells, and responses to decreased oxygen levels. Abbreviations 
      Inducible nitric oxide synthase (INOS), neutrophil cytosolic factor 1 (p47phox), 
      adrenomedullin (ADM), atrial natriuretic peptide (ANP), osteopontin (OPN/SPP1), 
      angiotensin converting enzyme (ACE), monocyte chemotactic protein 1 (MCP-1), 
      cytochrome b-245 beta polypeptide (gp91phox), intercellular adhesion molecule 1 
      (ICAM-1), transforming growth factor beta 1 (TGF-beta1), connective tissue growth 
      factor (CTGF), endothelin-1 (ET-1), cytochrome B-245, alpha polypeptide 
      (p22phox), endothelin receptor type B (ETB/EDNRB), brain natriuretic peptide 
      (BNP), endothelin receptor type A (ETA/EDNRA), matrix metallopeptidase 13 
      (MMP13), type I collagen (Col1a1), matrix metallopeptidase 2 (MMP2), TIMP 
      metallopeptidase inhibitor 1 (TIMP1), Type III collagen (Col3a1), interleukin 1 
      beta (IL-1beta), beta myocin heavy chain (beta-MHC), endothelin converting enzyme 1 
      (ECE1) matrix metallopeptidase 14 (MMP14), angiotensinogen (AGT), angiotensin II 
      receptor Type 1 (AT1R), cytochrome C oxidase I (COX1), fms-like tyrosine kinase 1 
      (FLT1), TIMP metallopeptidase inhibitor 2 (TIMP2), phospholamban (PLN), vascular 
      cell adhesion molecule 1 (VCAM1), extracellular matrix (ECM).
FAU - Yim, Jeffrey
AU  - Yim J
AD  - a Department of Medicine (Cardiology) , University of British Columbia , 
      Vancouver , BC , Canada.
FAU - Cho, Hyokeun
AU  - Cho H
AD  - a Department of Medicine (Cardiology) , University of British Columbia , 
      Vancouver , BC , Canada.
FAU - Rabkin, Simon W
AU  - Rabkin SW
AD  - a Department of Medicine (Cardiology) , University of British Columbia , 
      Vancouver , BC , Canada.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20171115
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - *Gene Expression
MH  - Heart Failure/genetics/*physiopathology
MH  - Hypertension/genetics/*physiopathology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Dahl
MH  - Stroke Volume
OTO - NOTNLM
OT  - Dahl rat
OT  - gene expression
OT  - heart failure with preserved ejection fraction
OT  - sodium-induced hypertension
EDAT- 2017/11/16 06:00
MHDA- 2018/06/28 06:00
CRDT- 2017/11/16 06:00
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2018/06/28 06:00 [medline]
PHST- 2017/11/16 06:00 [entrez]
AID - 10.1080/10641963.2017.1346113 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2018;40(2):155-166. doi: 10.1080/10641963.2017.1346113. Epub 
      2017 Nov 15.