PMID- 29140823
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1542-233X (Electronic)
IS  - 1542-2321 (Linking)
VI  - 44 Suppl 2
DP  - 2018 Nov
TI  - Single-Center Retrospective Study on Meibomian Gland Loss in Patients With Ocular 
      Chronic Graft-Versus-Host Disease.
PG  - S169-S175
LID - 10.1097/ICL.0000000000000445 [doi]
AB  - OBJECTIVES: This study aimed to analyze the influencing factors of meibomian 
      gland loss in patients with ocular chronic graft-versus-host disease (GVHD) and 
      its correlation with other clinical ocular surface assessment indexes. METHODS: 
      The clinical data of patients with ocular chronic GVHD from the ocular surface 
      and corneal outpatient clinic of the First Affiliated Hospital of Soochow 
      University were reviewed from June 2012 to June 2016. The relationship between 
      the percentage of meibomian gland acinar area and the influencing factors, such 
      as patient's sex, age, transplantation method, human leukocyte antigen (HLA) 
      matching, the time when eye discomfort appeared after transplantation (month), 
      and the severity of ocular chronic GVHD, was investigated. Moreover, the 
      correlation between the percentage of meibomian gland acinar area and other 
      ocular surface assessment indexes, such as subjective ocular symptom score, 
      eyelid margin score, tear film break-up time, corneal and conjunctival staining 
      score, and the Schirmer test, was analyzed. RESULTS: A linear relationship was 
      found between the percentage of meibomian gland acinar area and the severity of 
      ocular chronic GVHD, but no linear relationship existed between the percentage of 
      meibomian gland acinar area and the factors such as sex, age, transplantation 
      method, HLA matching, and the time when eye discomfort appeared after 
      transplantation. A negative correlation was observed between the percentage of 
      meibomian gland acinar area and eyelid margin score. CONCLUSIONS: The percentage 
      of meibomian gland acinar area can reflect the severity of ocular chronic GVHD. 
      The clinical significance of the percentage of meibomian gland acinar area needs 
      further investigation.
FAU - Que, Lijuan
AU  - Que L
AD  - Department of Ophthalmology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Zhang, Xiaofeng
AU  - Zhang X
FAU - Li, Mengmeng
AU  - Li M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Eye Contact Lens
JT  - Eye & contact lens
JID - 101160941
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chronic Disease
MH  - Conjunctival Diseases/*pathology
MH  - Corneal Diseases/*pathology
MH  - Female
MH  - Graft vs Host Disease/*pathology
MH  - Humans
MH  - Male
MH  - Meibomian Glands/*pathology
MH  - Middle Aged
MH  - Regression Analysis
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2017/11/16 06:00
MHDA- 2018/12/12 06:00
CRDT- 2017/11/16 06:00
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/11/16 06:00 [entrez]
AID - 10.1097/ICL.0000000000000445 [doi]
PST - ppublish
SO  - Eye Contact Lens. 2018 Nov;44 Suppl 2:S169-S175. doi: 
      10.1097/ICL.0000000000000445.