PMID- 29141503
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20240314
IS  - 1752-8976 (Electronic)
IS  - 1470-3203 (Print)
IS  - 1470-3203 (Linking)
VI  - 18
IP  - 4
DP  - 2017 Oct-Dec
TI  - Association of the genetic and traditional risk factors of ischaemic heart 
      disease with STEMI and NSTEMI development.
PG  - 1470320317739987
LID - 10.1177/1470320317739987 [doi]
LID - 1470320317739987
AB  - INTRODUCTION: To evaluate the influence of traditional risk factors of ischaemic 
      heart disease and genetic factors to predict different types of acute coronary 
      syndromes. MATERIALS AND METHODS: Five hundred and twenty-three patients with 
      acute coronary syndromes (393 with ST elevation myocardial infarction (STEMI) and 
      130 with non-ST elevation myocardial infarction (NSTEMI)) comprised the study 
      group. The control group consisted of 645 subjects free from symptoms of 
      ischaemic heart disease and stroke. Genetic polymorphisms of MMP-2 (-735) C/T, 
      MMP-2 (-1306) C/T, MMP-3 (-1171) 5A/6A, MMP-9 (-1562) C/T and ACE I/D were 
      evaluated using polymerase chain reaction. RESULTS: Patients with acute coronary 
      syndromes more often had ID or II genotype than DD genotype of ACE ( P = 0.04) 
      and 5A5A or 5A6A genotype than 6A6A genotype of MMP-3 ( P = 0.02) in comparison 
      to the control group. The genotypes of other matrix metalloproteinase genes did 
      not differ between the groups. 5A5A and 5A6A genotypes of MMP-3 (odds ratio (OR) 
      1.5; P = 0.021), II and ID genotypes of ACE (OR 1.7; P = 0.006) along with 
      traditional ischaemic heart disease risk factors such as smoking (OR 4.9; P = 
      0.001), hypertension (OR 2.0; P = 0.001), diabetes mellitus (OR 2.9; P = 0.001) 
      and dyslipidaemia (OR 2.1; P = 0.001) increased the risk of STEMI. However, the 
      polymorphism of MMP-3 5A/6A and ACE I/D was not associated with the occurrence of 
      NSTEMI. CONCLUSIONS: Genetic polymorphisms of MMP-3 5A/6A and ACE I/D along with 
      conventional ischaemic heart disease risk factors increase the risk of the 
      occurrence of STEMI, while having no influence on the pathogenesis of NSTEMI.
FAU - Zaliaduonyte-Peksiene, Diana
AU  - Zaliaduonyte-Peksiene D
AD  - 1 Department of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
FAU - Lesauskaite, Vaiva
AU  - Lesauskaite V
AD  - 2 Institute of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
FAU - Liutkeviciene, Rasa
AU  - Liutkeviciene R
AD  - 3 Neuroscience Institute, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
FAU - Tamakauskas, Vytenis
AU  - Tamakauskas V
AD  - 1 Department of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
FAU - Kviesulaitis, Vilius
AU  - Kviesulaitis V
AD  - 1 Department of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
FAU - Sinkunaite-Marsalkiene, Giedre
AU  - Sinkunaite-Marsalkiene G
AD  - 2 Institute of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
FAU - Simonyte, Sandrita
AU  - Simonyte S
AD  - 2 Institute of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
FAU - Maciulskyte, Simonita
AU  - Maciulskyte S
AD  - 1 Department of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
FAU - Tamuleviciute-Prasciene, Egle
AU  - Tamuleviciute-Prasciene E
AD  - 1 Department of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
FAU - Gustiene, Olivija
AU  - Gustiene O
AD  - 1 Department of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
FAU - Tamosiunas, Abdonas
AU  - Tamosiunas A
AD  - 2 Institute of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
FAU - Zaliunas, Remigijus
AU  - Zaliunas R
AD  - 1 Department of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, Lithuania.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Renin Angiotensin Aldosterone Syst
JT  - Journal of the renin-angiotensin-aldosterone system : JRAAS
JID - 100971636
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Matrix Metalloproteinases/genetics
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Non-ST Elevated Myocardial Infarction/*genetics
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/*genetics
PMC - PMC5843915
OTO - NOTNLM
OT  - Risk factors
OT  - genetic polymorphism
OT  - myocardial infarction
COIS- Declaration of conflicting interest: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2017/11/17 06:00
MHDA- 2018/07/28 06:00
PMCR- 2017/11/15
CRDT- 2017/11/17 06:00
PHST- 2017/11/17 06:00 [entrez]
PHST- 2017/11/17 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/11/15 00:00 [pmc-release]
AID - 10.1177_1470320317739987 [pii]
AID - 10.1177/1470320317739987 [doi]
PST - ppublish
SO  - J Renin Angiotensin Aldosterone Syst. 2017 Oct-Dec;18(4):1470320317739987. doi: 
      10.1177/1470320317739987.