PMID- 29141576
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20181202
IS  - 1874-0758 (Electronic)
IS  - 1872-3128 (Linking)
VI  - 11
IP  - 2
DP  - 2017
TI  - Analysis of Elevated Levels of Nandrolone Decanoate Induced Cytochrome- P450 
      Alterations in Mice.
PG  - 86-92
LID - 10.2174/1872312811666171114145535 [doi]
AB  - BACKGROUND: Frequent recreational use of Anabolic Androgenic Steroids (AAS) is an 
      instance of substance abuse which mimics the status of a natural hormone and upon 
      prolonged exposure may lead to adverse drug reactions. These adverse drug 
      reactions proceed in a manner so as to alter the normal metabolism of an enzyme 
      mediated pathway such as the Cytochrome P450 (CYP) family of enzymes. OBJECTIVE: 
      The present study was conducted to investigate the impact of overuse of 
      Nandrolone Decanoate (ND), an AAS, upon CYP enzyme activity and a CYP gene, 
      belonging to CYP1 family. METHODS: The study was carried out using normal and ND 
      treated male albino mice. Genetic analysis was conducted using normalized and 
      treated cDNA and reverse transcriptase polymerase chain reaction based assays. 
      For enzyme assay, 0.1ml of 25 mg ND was administered to the animals twice a week 
      for a period of 90 days. Genetic analysis was carried out with the same dose but 
      administered for a period of 360 days. RESULTS: CYP enzyme activity increased 
      significantly (p<0.01) in the ND treated group of animals compared to that in the 
      normal group. However, no noticeable alteration was observed at the molecular 
      level. CONCLUSION: From the present study it could be inferred that, at elevated 
      doses, ND has the potential to alter hepatic CYP enzyme activity without any 
      modification in the CYP gene. This could be due to a possible adaptive response 
      of the living system to such drugs.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Chowdhury, Parmita
AU  - Chowdhury P
AD  - Department of Zoology, Faculty of Sciences, Gauhati University, Guwahati, Assam, 
      India.
FAU - Mahanta, Rita
AU  - Mahanta R
AD  - Department of Zoology, Faculty of Sciences, Cotton College, Guwahati, Assam, 
      India.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Drug Metab Lett
JT  - Drug metabolism letters
JID - 101313587
RN  - 0 (Anabolic Agents)
RN  - 6PG9VR430D (Nandrolone)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A2)
RN  - EC 1.14.14.1 (cytochrome P-450 1A2, mouse)
RN  - H45187T098 (Nandrolone Decanoate)
SB  - IM
MH  - Anabolic Agents/*adverse effects
MH  - Animals
MH  - Cytochrome P-450 CYP1A2/genetics/*metabolism
MH  - Disease Models, Animal
MH  - Enzyme Assays
MH  - Humans
MH  - Injections, Intramuscular
MH  - Liver/drug effects/*enzymology
MH  - Male
MH  - Mice
MH  - Nandrolone/adverse effects/*analogs & derivatives
MH  - Nandrolone Decanoate
MH  - Substance-Related Disorders/*enzymology/etiology
OTO - NOTNLM
OT  - Anabolic androgenic steroid
OT  - Cyp1a2
OT  - Cytochrome P450
OT  - Drug abuse
OT  - Mice
OT  - Nandrolone Decanoate
EDAT- 2017/11/17 06:00
MHDA- 2018/10/23 06:00
CRDT- 2017/11/17 06:00
PHST- 2017/03/03 00:00 [received]
PHST- 2017/10/09 00:00 [revised]
PHST- 2017/10/31 00:00 [accepted]
PHST- 2017/11/17 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2017/11/17 06:00 [entrez]
AID - DML-EPUB-86865 [pii]
AID - 10.2174/1872312811666171114145535 [doi]
PST - ppublish
SO  - Drug Metab Lett. 2017;11(2):86-92. doi: 10.2174/1872312811666171114145535.