PMID- 29141763
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 98
IP  - 1
DP  - 2018 Jan
TI  - Pilot Study of the Addition of Mass Treatment for Malaria to Existing 
      School-Based Programs to Treat Neglected Tropical Diseases.
PG  - 95-99
LID - 10.4269/ajtmh.17-0590 [doi]
AB  - Malaria and neglected tropical diseases (NTDs), including schistosomiasis and 
      soil transmitted helminths, threaten the health of school aged in sub-Saharan 
      Africa. Established school-based mass drug administration (MDA) programs are used 
      to control NTDs. Recent clinical trials have shown benefit of mass treatment of 
      malaria in schools. The potential of adding malaria treatment to existing NTD 
      programs has not been thoroughly evaluated. We offered malaria treatment with 
      artemether-lumefantrine during routine NTD MDA and developed peer education 
      programs in two primary schools in southern Malawi. We assessed participation, 
      safety, and tolerability of coadministration of artemether-lumefantrine with 
      praziquantel and albendazole. Results were compared with two schools conducting 
      standard NTD MDA with additional monitoring by study staff. A total of 3,387 
      students (68%) received the standard NTD MDA. Among parents who came to schools 
      on the day of the MDA, malaria treatment was well accepted; 87% of students who 
      received the standard NTD MDA in intervention schools also consented for 
      treatment with artemether-lumefantrine. The most frequent treatment emergent 
      adverse events (AEs) were headache and vomiting. However, AEs were rare and were 
      not more frequent in students who received artemether-lumefantrine in addition to 
      praziquantel and albendazole. In this study, we found that the addition of 
      malaria treatment to NTD MDA is well-received and safe. Such integrated programs 
      may leverage existing infrastructures to reduce intervention costs and could 
      become the framework for further integrated school-based health programs.
FAU - Cohee, Lauren M
AU  - Cohee LM
AD  - Division of Malaria Research, Institute for Global Health, University of Maryland 
      School of Medicine, Baltimore, Maryland.
FAU - Chilombe, Moses
AU  - Chilombe M
AD  - Malaria Alert Center, University of Malawi College of Medicine, Blantyre, Malawi.
FAU - Ngwira, Andrew
AU  - Ngwira A
AD  - Malaria Alert Center, University of Malawi College of Medicine, Blantyre, Malawi.
FAU - Jemu, Samuel K
AU  - Jemu SK
AD  - Ministry of Health Malawi, Lilongwe, Malawi.
FAU - Mathanga, Don P
AU  - Mathanga DP
AD  - Malaria Alert Center, University of Malawi College of Medicine, Blantyre, Malawi.
FAU - Laufer, Miriam K
AU  - Laufer MK
AD  - Division of Malaria Research, Institute for Global Health, University of Maryland 
      School of Medicine, Baltimore, Maryland.
LA  - eng
GR  - K24 AI114996/AI/NIAID NIH HHS/United States
GR  - T32 AI005284/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Anthelmintics)
RN  - 0 (Antimalarials)
RN  - 0 (Artemether, Lumefantrine Drug Combination)
RN  - 6490C9U457 (Praziquantel)
RN  - F4216019LN (Albendazole)
SB  - IM
MH  - Adolescent
MH  - Albendazole/administration & dosage/adverse effects/therapeutic use
MH  - Anthelmintics/administration & dosage/adverse effects/therapeutic use
MH  - Antimalarials/*administration & dosage/adverse effects/therapeutic use
MH  - Artemether, Lumefantrine Drug Combination/*administration & dosage/adverse 
      effects/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Drug Therapy, Combination/adverse effects/methods
MH  - Female
MH  - Helminthiasis/prevention & control
MH  - Humans
MH  - Malaria/*prevention & control
MH  - Malawi
MH  - Male
MH  - Mass Drug Administration/*methods
MH  - Neglected Diseases/*prevention & control
MH  - Pilot Projects
MH  - Praziquantel/administration & dosage/adverse effects/therapeutic use
MH  - School Health Services
PMC - PMC5928736
EDAT- 2017/11/17 06:00
MHDA- 2018/12/12 06:00
PMCR- 2017/11/06
CRDT- 2017/11/17 06:00
PHST- 2017/11/17 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/11/17 06:00 [entrez]
PHST- 2017/11/06 00:00 [pmc-release]
AID - tpmd170590 [pii]
AID - 10.4269/ajtmh.17-0590 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2018 Jan;98(1):95-99. doi: 10.4269/ajtmh.17-0590.