PMID- 29142746
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2049-9450 (Print)
IS  - 2049-9469 (Electronic)
IS  - 2049-9450 (Linking)
VI  - 7
IP  - 5
DP  - 2017 Nov
TI  - Interaction between Merkel cell carcinoma and the immune system: Pathogenetic and 
      therapeutic implications.
PG  - 729-732
LID - 10.3892/mco.2017.1406 [doi]
AB  - Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous 
      neuroendocrine carcinoma. It usually appears on the face and neck of elderly 
      Caucasian people as a flesh-colored, erythematous or violaceous dome-shaped, 
      non-tender nodule with a smooth surface. In immunocompromised patients with 
      T-cell dysfunction, such as patients with acquired immunodeficiency syndrome 
      (AIDS) or solid organ transplant recipients, the incidence of this disease is 
      markedly increased. This suggests a link between the development of MCC and the 
      immune system. Merkel cell polyolmavirus (MCPyV) is clonally integrated into the 
      majority of MCCs, suggesting its causative role in the pathogenesis of the 
      majority of these tumors. Despite wide local excision, sentinel lymph node 
      biopsy, and eventually, adjuvant radiation therapy, which remains the first-line 
      treatment for MCC, the identification of MCPyV has opened novel therapeutic 
      insights. Novel therapeutic strategies could be to inhibit MCPyV oncoproteins and 
      to stimulate immune responses against virus-infected tumor cells by 
      immunostimulatory cytokines, including interferons and interleukin-2.
FAU - Zanetti, Irene
AU  - Zanetti I
AD  - Unit of Dermatology, University of Padua, I-35128 Padua, Italy.
FAU - Coati, Ilaria
AU  - Coati I
AD  - Unit of Dermatology, University of Padua, I-35128 Padua, Italy.
FAU - Alaibac, Mauro
AU  - Alaibac M
AD  - Unit of Dermatology, University of Padua, I-35128 Padua, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170901
PL  - England
TA  - Mol Clin Oncol
JT  - Molecular and clinical oncology
JID - 101613422
PMC - PMC5666639
OTO - NOTNLM
OT  - Merkel cell carcinoma
OT  - immunity
OT  - skin cancer
EDAT- 2017/11/17 06:00
MHDA- 2017/11/17 06:01
PMCR- 2017/09/01
CRDT- 2017/11/17 06:00
PHST- 2016/11/23 00:00 [received]
PHST- 2017/04/11 00:00 [accepted]
PHST- 2017/11/17 06:00 [entrez]
PHST- 2017/11/17 06:00 [pubmed]
PHST- 2017/11/17 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - MCO-0-0-1406 [pii]
AID - 10.3892/mco.2017.1406 [doi]
PST - ppublish
SO  - Mol Clin Oncol. 2017 Nov;7(5):729-732. doi: 10.3892/mco.2017.1406. Epub 2017 Sep 
      1.