PMID- 29142810
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220310
IS  - 2211-4122 (Print)
IS  - 2347-193X (Electronic)
IS  - 2211-4122 (Linking)
VI  - 27
IP  - 4
DP  - 2017 Oct-Dec
TI  - The role of Ivabradine in Diastolic Heart Failure with preserved Ejection 
      Fraction. A Doppler-Echocardiographic study.
PG  - 126-131
LID - 10.4103/jcecho.jcecho_6_17 [doi]
AB  - BACKGROUND: Ivabradine (IVA) is effective in patients with coronary artery 
      disease (CAD) or systolic heart failure in sinus rhythm. Its action consists in 
      reducing heart rate (HR) and improving the time of left ventricular (LV) 
      diastolic filling. The aim of this study was to evaluate the effects of IVA added 
      to conventional therapy on patients with diastolic heart failure (DHF) and 
      preserved ejection fraction (HFpEF). METHODS: We evaluated 25 patients with DHF 
      in the New York Heart Association (NYHA) Class II-III and sinus rhythm. In these, 
      IVA per os (5 mg/twice a day) was added to the conventional medical therapy and 
      given for 12 weeks. Immediately before the beginning of IVA therapy and 3 months 
      later, patients underwent echocardiographic evaluation by two-dimensional (2D) 
      ultrasound and tissue Doppler imaging (TDI). The patterns of diastolic mitral 
      inflow and pulmonary venous flow were recorded using 2D echocardiography, while 
      the diastolic phase of mitral flow was recorded by TDI, from the lateral mitral 
      annulus. RESULTS: Three months after the addition of IVA to conventional 
      treatment, HR significantly decreased in comparison to the baseline values. On 
      the contrary, the echocardiographic indexes of LV diastolic dysfunction improved. 
      CONCLUSIONS: These results testify that the addition of IVA to conventional 
      therapy in patients with HFpEF can improve LV diastolic function evaluated by 2D 
      and tissue Doppler-echocardiographic patterns. These Doppler-echocardiographic 
      results match with the clinical improvement of patients evaluated.
FAU - Cacciapuoti, Federico
AU  - Cacciapuoti F
AD  - Department of Internal Medicine, Ambulatory of Echocardiography, "Luigi 
      Vanvitelli" University, Naples, Italy.
FAU - Magro, Valerio Massimo
AU  - Magro VM
AD  - Department of Internal Medicine, Ambulatory of Echocardiography, "Luigi 
      Vanvitelli" University, Naples, Italy.
FAU - Caturano, Michele
AU  - Caturano M
AD  - Department of Internal Medicine, Ambulatory of Echocardiography, "Luigi 
      Vanvitelli" University, Naples, Italy.
FAU - Lama, Diana
AU  - Lama D
AD  - Department of Internal Medicine, Ambulatory of Echocardiography, "Luigi 
      Vanvitelli" University, Naples, Italy.
FAU - Cacciapuoti, Fulvio
AU  - Cacciapuoti F
AD  - Department of Internal Medicine, Ambulatory of Echocardiography, "Luigi 
      Vanvitelli" University, Naples, Italy.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cardiovasc Echogr
JT  - Journal of cardiovascular echography
JID - 101562228
PMC - PMC5672684
OTO - NOTNLM
OT  - Diastolic heart failure with preserved ejection fraction
OT  - Doppler-echocardiographic parameters
OT  - ivabradine
OT  - left ventricular diastolic function
COIS- There are no conflicts of interest.
EDAT- 2017/11/17 06:00
MHDA- 2017/11/17 06:01
PMCR- 2017/10/01
CRDT- 2017/11/17 06:00
PHST- 2017/11/17 06:00 [entrez]
PHST- 2017/11/17 06:00 [pubmed]
PHST- 2017/11/17 06:01 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - JCE-27-126 [pii]
AID - 10.4103/jcecho.jcecho_6_17 [doi]
PST - ppublish
SO  - J Cardiovasc Echogr. 2017 Oct-Dec;27(4):126-131. doi: 10.4103/jcecho.jcecho_6_17.