PMID- 29145008
OWN - NLM
STAT- MEDLINE
DCOM- 20190410
LR  - 20190410
IS  - 1878-4291 (Electronic)
IS  - 0968-4328 (Linking)
VI  - 105
DP  - 2018 Feb
TI  - Morphological changes in erythrocytes of people with type 2 diabetes mellitus 
      evaluated with atomic force microscopy: A brief review.
PG  - 11-17
LID - S0968-4328(17)30351-7 [pii]
LID - 10.1016/j.micron.2017.11.001 [doi]
AB  - Prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. 
      Cardiovascular diseases are one of the main causes of death among people with 
      T2DM. Morphological changes in erythrocytes have been associated with higher risk 
      of cardiovascular diseases. Atomic force microscopy (AFM) is a new technique that 
      allows non-invasive imaging of cells and the evaluation of changes in mechanical 
      properties. AIM: To evaluate by AFM the erythrocytes morphological changes of 
      people with T2DM METHODS: Search was conducted from in PubMed, ScienceDirect, 
      Scielo, and Lilacs. Erythrocyte, type 2 Diabetes Mellitus and, Microscopy, Atomic 
      Force were the keywords used for the search. Papers included were cross-sectional 
      studies performed in humans. RESULTS: Five of seven articles fulfilled the 
      inclusion criteria. Compared with healthy cells, the erythrocytes from 
      individuals affected by T2DM had morphological changes such as a decreased 
      concave depth, diameter, height and a deformation index, while axial ratio, 
      stiffness, adhesive force, aggregation, and rigidity index were increased. The 
      results regarding the erythrocyte roughness were inconclusive. CONCLUSIONS: The 
      AFM is an excellent instrument to study the altered erythrocytes of subjects 
      affected by T2DM. Morphology changes in erythrocytes could lead to cardiovascular 
      events, which are major complications in people living with this disease.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Loyola-Leyva, Alejandra
AU  - Loyola-Leyva A
AD  - Basic Biomedical Sciences Doctoral Program, Faculty of Medicine, San Luis Potosi 
      Autonomous University, Avenida Venustiano Carranza 2405, Los Filtros, 78210, San 
      Luis, S.L.P, Mexico. Electronic address: aleloleyva@yahoo.com.mx.
FAU - Loyola-Rodriguez, Juan Pablo
AU  - Loyola-Rodriguez JP
AD  - Faculty of Dentistry, Baja California Autonomous University, Blvd. Univesitario 
      1000, Unidad Valle de las Palmas, Tijuana, Baja California, Mexico. Electronic 
      address: juanpablo.loyola8@gmail.com.
FAU - Atzori, Marco
AU  - Atzori M
AD  - Faculty of Sciences, San Luis Potosi Autonomous University, Lateral Av. Salvador 
      Nava, Lomas, 78290, San Luis, S.L.P, Mexico. Electronic address: 
      marco_atzori@hotmail.com.
FAU - Gonzalez, Francisco Javier
AU  - Gonzalez FJ
AD  - Innovation and Application of Science and Technology Center (CIACyT), San Luis 
      Potosi Autonomous University, Avenida Sierra Leona 550, Lomas 2 feminine seccion, 78210, 
      San Luis, S.L.P, Mexico. Electronic address: javier.gonzalez@uaslp.mx.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20171110
PL  - England
TA  - Micron
JT  - Micron (Oxford, England : 1993)
JID - 9312850
SB  - IM
MH  - Cardiovascular Diseases/blood/*pathology
MH  - Diabetes Mellitus, Type 2/blood/*pathology
MH  - Erythrocytes/*cytology
MH  - Humans
MH  - Microscopy, Atomic Force/*methods
MH  - Prognosis
MH  - Risk
OTO - NOTNLM
OT  - Atomic force microscopy
OT  - Cardiovascular diseases
OT  - Erythrocytes
OT  - Morphology
OT  - Type 2 diabetes mellitus
EDAT- 2017/11/18 06:00
MHDA- 2019/04/11 06:00
CRDT- 2017/11/18 06:00
PHST- 2017/09/18 00:00 [received]
PHST- 2017/11/01 00:00 [revised]
PHST- 2017/11/02 00:00 [accepted]
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2019/04/11 06:00 [medline]
PHST- 2017/11/18 06:00 [entrez]
AID - S0968-4328(17)30351-7 [pii]
AID - 10.1016/j.micron.2017.11.001 [doi]
PST - ppublish
SO  - Micron. 2018 Feb;105:11-17. doi: 10.1016/j.micron.2017.11.001. Epub 2017 Nov 10.