PMID- 29145468
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 11
DP  - 2017
TI  - The effects of non-surgical periodontal treatment on glycemic control, oxidative 
      stress balance and quality of life in patients with type 2 diabetes: A randomized 
      clinical trial.
PG  - e0188171
LID - 10.1371/journal.pone.0188171 [doi]
LID - e0188171
AB  - AIM: The purpose of this study was to investigate the effects of non-surgical 
      periodontal treatment on hemoglobinA1c (HbA1c) levels, oxidative stress balance 
      and quality of life (QOL) in patients with type 2 diabetes mellitus (T2DM) 
      compared to no periodontal treatment (simple oral hygiene instructions only). 
      METHODS: The design was a 6-month, single-masked, single center, randomized 
      clinical trial. Patients had both T2DM and chronic periodontitis. Forty 
      participants were enrolled between April 2014 and March 2016 at the Nephrology, 
      Diabetology and Endocrinology Department of Okayama University Hospital. The 
      periodontal treatment group (n = 20) received non-surgical periodontal therapy, 
      including scaling and root planing plus oral hygiene instructions, and 
      consecutive supportive periodontal therapy at 3 and 6 months. The control group 
      (n = 17) received only oral hygiene instructions without treatment during the 
      experimental period. The primary study outcome was the change in HbA1c levels 
      from baseline to 3 months. Secondary outcomes included changes in oxidative 
      stress balance (Oxidative-INDEX), the Diabetes Therapy-Related QOL and clinical 
      periodontal parameters from baseline to 3 months and baseline to 6 months. 
      RESULTS: Changes in HbA1c in the periodontal treatment group were not 
      significantly different with those in the control group at 3 and 6 months. 
      Systemic oxidative stress balance and QOL significantly improved in the 
      periodontal treatment group compared to the control group at 3 months. In the 
      subgroup analysis (moderately poor control of diabetes), the decrease in HbA1c 
      levels in the periodontal treatment group was greater than that in the control 
      group at 3 months but not significant. CONCLUSIONS: In T2DM patients, 
      non-surgical periodontal treatment improved systemic oxidative stress balance and 
      QOL, but did not decrease HbA1c levels at 3 months follow-up. TRIAL REGISTRATION: 
      Current Controlled Trials UMIN-ICDR UMIN 000013278 (Registered April 1, 2014).
FAU - Mizuno, Hirofumi
AU  - Mizuno H
AD  - Department of Preventive Dentistry, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Ekuni, Daisuke
AU  - Ekuni D
AUID- ORCID: 0000-0002-1876-5605
AD  - Department of Preventive Dentistry, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
AD  - Advanced Research Center for Oral and Craniofacial Sciences, Okayama University 
      Dental School, Okayama, Japan.
FAU - Maruyama, Takayuki
AU  - Maruyama T
AD  - Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, 
      Japan.
FAU - Kataoka, Kota
AU  - Kataoka K
AD  - Department of Preventive Dentistry, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Yoneda, Toshiki
AU  - Yoneda T
AD  - Department of Preventive Dentistry, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Fukuhara, Daiki
AU  - Fukuhara D
AD  - Department of Preventive Dentistry, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Sugiura, Yoshio
AU  - Sugiura Y
AD  - Department of Preventive Dentistry, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Tomofuji, Takaaki
AU  - Tomofuji T
AD  - Department of Community Oral Health, Asahi University School of Dentistry, 
      Mizuho, Japan.
FAU - Wada, Jun
AU  - Wada J
AD  - Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama 
      University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 
      Okayama, Japan.
FAU - Morita, Manabu
AU  - Morita M
AD  - Department of Preventive Dentistry, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20171116
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*complications/metabolism
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Periodontitis/complications/metabolism/*therapy
MH  - Single-Blind Method
MH  - Treatment Outcome
PMC - PMC5689834
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/11/18 06:00
MHDA- 2017/12/27 06:00
PMCR- 2017/11/16
CRDT- 2017/11/18 06:00
PHST- 2017/06/06 00:00 [received]
PHST- 2017/10/31 00:00 [accepted]
PHST- 2017/11/18 06:00 [entrez]
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
PHST- 2017/11/16 00:00 [pmc-release]
AID - PONE-D-17-18934 [pii]
AID - 10.1371/journal.pone.0188171 [doi]
PST - epublish
SO  - PLoS One. 2017 Nov 16;12(11):e0188171. doi: 10.1371/journal.pone.0188171. 
      eCollection 2017.