PMID- 29146987
OWN - NLM
STAT- MEDLINE
DCOM- 20190705
LR  - 20190705
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Nov 16
TI  - Homocysteine in retinal artery occlusive disease: A meta-analysis of cohort 
      studies.
PG  - 15708
LID - 10.1038/s41598-017-16065-2 [doi]
LID - 15708
AB  - Few studies have reported the relationship between retinal artery occlusion (RAO) 
      and plasma homocysteine (Hcy) levels. Our goal was to evaluate the association 
      between the plasma Hcy level and the risk of RAO disease. Several databases were 
      searched for all published studies that involved Hcy and RAO. Six studies 
      evaluated hyperhomocysteinemia (hHcy) in retinal artery occlusion patients and 
      controls; the incidence of hHcy in patients with RAO was higher than the control 
      and the pooled odds ratio (OR) was 6.64 (95% confidence interval (CI): 3.42, 
      12.89). Subgroup analyses showed that the ORs were 4.77 (95% CI: 2.69, 8.46) in 
      Western countries, 22.19 (95% CI: 2.46, 200.37) in Asian countries, 9.70 (95% CI: 
      4.43, 21.20) in the age matched group, 11.41 (95% CI: 3.32, 39.18) in the sex 
      matched group, 9.70 (95% CI: 4.37, 21.53) in the healthy control group, and 6.82 
      (95% CI: 4.19, 11.10) in the sample size >30. The mean plasma Hcy level from 5 
      case-control studies was higher than controls, and the weighted mean difference 
      (WMD) was 6.54 (95% CI: 2.79, 10.29). Retinal artery occlusion is associated with 
      elevated plasma Hcy levels. Our study results suggest that hHcy is probably an 
      independent risk factor for RAO.
FAU - Huang, Xuetao
AU  - Huang X
AD  - Department of Ophthalmology, Changsha Aier Hospital, Aier School of 
      Ophthalmology, Central South University, Changsha, 410007, China.
AD  - Department of Ophthalmology, Huaihe Hospital of Henan University, Kaifeng, 
      475000, China.
FAU - Yang, Yezhen
AU  - Yang Y
AD  - Department of Ophthalmology, Changsha Aier Hospital, Aier School of 
      Ophthalmology, Central South University, Changsha, 410007, China.
FAU - Duan, Yiqin
AU  - Duan Y
AD  - Department of Ophthalmology, Changsha Aier Hospital, Aier School of 
      Ophthalmology, Central South University, Changsha, 410007, China.
FAU - Kuang, Yi-Qun
AU  - Kuang YQ
AUID- ORCID: 0000-0002-1452-4388
AD  - Institute of Infection and Immunity, Henan University & Centre for Translational 
      Medicine, Huaihe Clinical College, Huaihe Hospital of Henan University, Kaifeng, 
      475000, China. yqkuang@henu.edu.cn.
FAU - Lin, Ding
AU  - Lin D
AD  - Department of Ophthalmology, Changsha Aier Hospital, Aier School of 
      Ophthalmology, Central South University, Changsha, 410007, China. 
      dinglinoph@126.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20171116
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Homocysteine/blood/*metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/blood
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Publication Bias
MH  - Retinal Artery Occlusion/blood/*metabolism
MH  - Risk Factors
MH  - Sensitivity and Specificity
PMC - PMC5691205
COIS- The authors declare that they have no competing interests.
EDAT- 2017/11/18 06:00
MHDA- 2019/07/06 06:00
PMCR- 2017/11/16
CRDT- 2017/11/18 06:00
PHST- 2016/08/11 00:00 [received]
PHST- 2017/11/07 00:00 [accepted]
PHST- 2017/11/18 06:00 [entrez]
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2019/07/06 06:00 [medline]
PHST- 2017/11/16 00:00 [pmc-release]
AID - 10.1038/s41598-017-16065-2 [pii]
AID - 16065 [pii]
AID - 10.1038/s41598-017-16065-2 [doi]
PST - epublish
SO  - Sci Rep. 2017 Nov 16;7(1):15708. doi: 10.1038/s41598-017-16065-2.