PMID- 29147492
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 20
IP  - 10
DP  - 2017 Oct
TI  - Alterations in adult hippocampal neurogenesis, aberrant protein s-nitrosylation, 
      and associated spatial memory loss in streptozotocin-induced diabetes mellitus 
      type 2 mice.
PG  - 1159-1165
LID - 10.22038/IJBMS.2017.9366 [doi]
AB  - OBJECTIVES: Epidemiological and biochemical studies conducted over the past two 
      decades have established a strong link between type 2 diabetes mellitus (T2DM) 
      and Alzheimer's disease (AD). However, the exact mechanisms through which 
      aberrations in insulin signaling associated with T2DM contribute to cognitive 
      decline are not yet known. MATERIALS AND METHODS: In an effort to explore 
      possible molecular links between T2DM and AD, the present study investigated the 
      status of neurodegeneration, adult hippocampal neurogenesis, and nitrosative 
      stress induced protein S-nitrosylation in streptozotocin (STZ) induced mice 
      models of T2DM. Morris water maze task and subsequent histological and 
      immunohistochemical assessment were conducted. Expression of neurogenesis markers 
      (Ki67, DCX, and NeuN) and APP 770 was determined by qRT-PCR. RESULTS: A 
      significant decline in spatial learning and reference memory was observed with 
      consequent neurodegeneration in brain cortex and hippocampus in the diabetic 
      group as compared to the control group. A subsequent increase in expression of 
      APP 770 was also observed in T2DM brain regions. Moreover, a significant decrease 
      in transcriptional expression of Ki67, DCX, and NeuN was also evident in T2DM 
      brain regions, which indicated possible aberrations in adult hippocampal 
      neurogenesis in T2DM. Furthermore, an increased immunohistochemical signal for 
      S-nitrosylation was also observed in T2DM, which also suggested its potential 
      contribution in T2DM associated neuronal deterioration. CONCLUSION: It is 
      suggested that these identified aberrations in the diabetic brain may communally 
      increase the susceptibility of developing AD in patients with T2DM. Further 
      studies of the underlying molecular mechanisms may help to strategize a 
      combination therapy for these debilitating disorders.
FAU - Noor, Aneeqa
AU  - Noor A
AD  - Neurobiology Research Laboratory, Department of Healthcare Biotechnology, 
      Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and 
      Technology, Islamabad, Pakistan.
FAU - Zahid, Saadia
AU  - Zahid S
AD  - Neurobiology Research Laboratory, Department of Healthcare Biotechnology, 
      Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and 
      Technology, Islamabad, Pakistan.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC5673701
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Neurodegeneration Neurogenesis
OT  - S-nitrosylation
OT  - Type 2 diabetes mellitus
EDAT- 2017/11/18 06:00
MHDA- 2017/11/18 06:01
PMCR- 2017/10/01
CRDT- 2017/11/18 06:00
PHST- 2017/11/18 06:00 [entrez]
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2017/11/18 06:01 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - IJBMS-20-1159 [pii]
AID - 10.22038/IJBMS.2017.9366 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2017 Oct;20(10):1159-1165. doi: 10.22038/IJBMS.2017.9366.