PMID- 29147589
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2090-6560 (Print)
IS  - 2090-6579 (Electronic)
IS  - 2090-6579 (Linking)
VI  - 2017
DP  - 2017
TI  - gammadelta T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric 
      Cases and Its Distinction from Other Mature gammadelta T-Cell Malignancies.
PG  - 5873015
LID - 10.1155/2017/5873015 [doi]
LID - 5873015
AB  - Gamma delta (gammadelta) T-cell antigen receptor (TCR) expression and its related T-cell 
      differentiation are not commonly reported in T-cell acute lymphoblastic 
      leukemia/lymphoma (T-ALL). Here we report two pediatric T-ALL cases and present 
      their clinical features, histology, immunophenotypes, cytogenetics, and molecular 
      diagnostic findings. The first patient is a two-year-old girl with leukocytosis, 
      circulating lymphoblasts, and a cryptic insertion of a short-arm segment at 10p12 
      into the long-arm segment of 11q23 resulting in an MLL and AF10 fusion 
      transcript, which may be the first reported in gammadelta T-ALL. She responded to the 
      chemotherapy protocol poorly and had persistent diseases. Following an allogeneic 
      bone marrow transplant, she went into remission. The second patient is an 
      eleven-year-old boy with a normal white cell count, circulating blasts, and a 
      normal karyotype, but without any immature cellular markers by flow cytometric 
      analysis. He responded to the chemotherapy well and achieved a complete 
      remission. These cases demonstrate the diverse phenotypic, cytogenetic, and 
      molecular aspects of gammadelta T-ALL. Early T-precursor- (ETP-) ALL and their 
      differential diagnosis from other mature gammadelta T-cell leukemia/lymphomas are also 
      discussed.
FAU - Wei, Eric X
AU  - Wei EX
AUID- ORCID: 0000-0002-5824-867X
AD  - Department of Pathology and Translational Pathobiology, LSU Health Shreveport, 
      Shreveport, LA, USA.
FAU - Leventaki, Vasiliki
AU  - Leventaki V
AD  - Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
FAU - Choi, John K
AU  - Choi JK
AD  - Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
FAU - Raimondi, Susana C
AU  - Raimondi SC
AD  - Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
FAU - Azzato, Elizabeth M
AU  - Azzato EM
AD  - Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
FAU - Shurtleff, Sheila A
AU  - Shurtleff SA
AD  - Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
FAU - Ong, Menchu G
AU  - Ong MG
AD  - Department of Pathology and Translational Pathobiology, LSU Health Shreveport, 
      Shreveport, LA, USA.
FAU - Veillon, Diana M
AU  - Veillon DM
AD  - Department of Pathology and Translational Pathobiology, LSU Health Shreveport, 
      Shreveport, LA, USA.
FAU - Cotelingam, James D
AU  - Cotelingam JD
AD  - Department of Pathology and Translational Pathobiology, LSU Health Shreveport, 
      Shreveport, LA, USA.
FAU - Shackelford, Rodney E
AU  - Shackelford RE
AD  - Department of Pathology and Translational Pathobiology, LSU Health Shreveport, 
      Shreveport, LA, USA.
LA  - eng
PT  - Case Reports
DEP - 20170924
PL  - United States
TA  - Case Rep Hematol
JT  - Case reports in hematology
JID - 101576456
PMC - PMC5632927
EDAT- 2017/11/18 06:00
MHDA- 2017/11/18 06:01
PMCR- 2017/09/24
CRDT- 2017/11/18 06:00
PHST- 2017/06/09 00:00 [received]
PHST- 2017/07/31 00:00 [revised]
PHST- 2017/08/14 00:00 [accepted]
PHST- 2017/11/18 06:00 [entrez]
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2017/11/18 06:01 [medline]
PHST- 2017/09/24 00:00 [pmc-release]
AID - 10.1155/2017/5873015 [doi]
PST - ppublish
SO  - Case Rep Hematol. 2017;2017:5873015. doi: 10.1155/2017/5873015. Epub 2017 Sep 24.