PMID- 29147909
OWN - NLM
STAT- MEDLINE
DCOM- 20180410
LR  - 20180410
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1037
DP  - 2017
TI  - The Role of the Antioxidant Protein DJ-1 in Type 2 Diabetes Mellitus.
PG  - 173-186
LID - 10.1007/978-981-10-6583-5_11 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a worldwide escalating health disorder 
      resulting from insulin resistance and functional loss of insulin-producing beta 
      cells that finally cause chronically elevated blood glucose concentrations. Here 
      we review the role of ubiquitously expressed antioxidant protein DJ-1 in the 
      pathogenesis of T2DM. In beta cells, DJ-1 protects against oxidative stress, 
      endoplasmic reticulum stress, and streptozotocin- and cytokine-induced stress and 
      preserves beta cell viability and insulin secretion. In skeletal muscle, DJ-1 
      controls energy metabolism and efficient fuel utilization, whereas in adipose 
      tissue a role in adipogenesis and obesity-induced inflammation has been reported. 
      This suggests that DJ-1 plays multiple roles in many cell types under 
      metabolically challenging conditions as seen in obesity, insulin resistance, and 
      T2DM.
FAU - Eberhard, Daniel
AU  - Eberhard D
AD  - Institute of Metabolic Physiology, Department of Biology, Heinrich Heine 
      University, D-40225, Dusseldorf, Germany. daniel.eberhard@hhu.de.
FAU - Lammert, Eckhard
AU  - Lammert E
AD  - Institute of Metabolic Physiology, Department of Biology, Heinrich Heine 
      University, D-40225, Dusseldorf, Germany. lammert@hhu.de.
AD  - Institute for Beta Cell Biology, German Diabetes Center, Leibniz Center for 
      Diabetes, Research at Heinrich Heine University, D-40225, Dusseldorf, Germany. 
      lammert@hhu.de.
AD  - German Center for Diabetes Research (DZD e.V.), D-85764, Munchen-Neuherberg, 
      Germany. lammert@hhu.de.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Antioxidants)
RN  - EC 3.1.2.- (Protein Deglycase DJ-1)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Energy Metabolism
MH  - Humans
MH  - *Insulin Resistance
MH  - Insulin-Secreting Cells/metabolism
MH  - Muscle, Skeletal/metabolism
MH  - Protein Deglycase DJ-1/*metabolism
OTO - NOTNLM
OT  - DJ-1
OT  - Diabetes mellitus
OT  - Insulin
OT  - Insulin resistance
OT  - Islets of Langerhans
OT  - Obesity
OT  - Park7
EDAT- 2017/11/18 06:00
MHDA- 2018/04/11 06:00
CRDT- 2017/11/18 06:00
PHST- 2017/11/18 06:00 [entrez]
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2018/04/11 06:00 [medline]
AID - 10.1007/978-981-10-6583-5_11 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2017;1037:173-186. doi: 10.1007/978-981-10-6583-5_11.