PMID- 29148756
OWN - NLM
STAT- MEDLINE
DCOM- 20181112
LR  - 20181112
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 65
IP  - 49
DP  - 2017 Dec 13
TI  - Inhibitory Activities of Compounds from the Marine Actinomycete Williamsia sp. 
      MCCC 1A11233 Variant on IgE-Mediated Mast Cells and Passive Cutaneous 
      Anaphylaxis.
PG  - 10749-10756
LID - 10.1021/acs.jafc.7b04314 [doi]
AB  - The compounds of the deep-sea-derived marine Williamsia sp. MCCC 1A11233 (CDMW) 
      were isolated, which are secondary metabolites of the actinomycetes. In this 
      study, seven kinds of CDMW were found to decrease degranulation and histamine 
      release in immunoglobulin E (IgE)-mediated rat basophilic leukemia (RBL)-2H3 
      cells. The production of cytokines (tumor necrosis factor-alpha, interleukin-4) was 
      inhibited by these CDMW in RBL-2H3 cells, and their chemical structures were 
      established mainly based on detailed analysis of their NMR spectra. CDMW-3, 
      CDMW-5, and CDMW-15 were further demonstrated to block mast cell-dependent 
      passive cutaneous anaphylaxis in IgE-sensitized mice. Bone marrow mononuclear 
      cells (BMMCs) were established to clarify the effect of CDMW-3, CDMW-5, and 
      CDMW-15 on mast cells. The seven kinds of CDMW decreased the degranulation and 
      histamine release of BMMCs. Furthermore, flow cytometry results indicated that 
      CDMW-3, CDMW-5, and CDMW-15 increased the annexin(+) cell population of BMMCs. In 
      conclusion, CDMW-3, CDMW-5, and CDMW-15 have obvious antiallergic activity due to 
      induction of the apoptosis of mast cells.
FAU - Gao, Yuan-Yuan
AU  - Gao YY
AD  - College of Food and Biological Engineering, Xiamen Key Laboratory of Marine 
      Functional Food, Fujian Provincial Engineering Technology Research Center of 
      Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation 
      and Utilization of Marine Biological Resources, Jimei University , 43 Yindou 
      Road, Xiamen 361021, Fujian, P. R. China.
FAU - Liu, Qing-Mei
AU  - Liu QM
AD  - College of Food and Biological Engineering, Xiamen Key Laboratory of Marine 
      Functional Food, Fujian Provincial Engineering Technology Research Center of 
      Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation 
      and Utilization of Marine Biological Resources, Jimei University , 43 Yindou 
      Road, Xiamen 361021, Fujian, P. R. China.
FAU - Liu, Bo
AU  - Liu B
AD  - College of Food and Biological Engineering, Xiamen Key Laboratory of Marine 
      Functional Food, Fujian Provincial Engineering Technology Research Center of 
      Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation 
      and Utilization of Marine Biological Resources, Jimei University , 43 Yindou 
      Road, Xiamen 361021, Fujian, P. R. China.
FAU - Xie, Chun-Lan
AU  - Xie CL
AD  - Key Laboratory of Marine Biogenetic Resources, South China Sea Bio-Resource 
      Exploitation and Utilization Collaborative Innovation Center, Third Institute of 
      Oceanography, State Oceanic Administration , 184 Daxue Road, Xiamen 361005, P. R. 
      China.
FAU - Cao, Min-Jie
AU  - Cao MJ
AD  - College of Food and Biological Engineering, Xiamen Key Laboratory of Marine 
      Functional Food, Fujian Provincial Engineering Technology Research Center of 
      Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation 
      and Utilization of Marine Biological Resources, Jimei University , 43 Yindou 
      Road, Xiamen 361021, Fujian, P. R. China.
FAU - Yang, Xian-Wen
AU  - Yang XW
AUID- ORCID: 0000-0002-4967-0844
AD  - Key Laboratory of Marine Biogenetic Resources, South China Sea Bio-Resource 
      Exploitation and Utilization Collaborative Innovation Center, Third Institute of 
      Oceanography, State Oceanic Administration , 184 Daxue Road, Xiamen 361005, P. R. 
      China.
FAU - Liu, Guang-Ming
AU  - Liu GM
AUID- ORCID: 0000-0002-8689-0504
AD  - College of Food and Biological Engineering, Xiamen Key Laboratory of Marine 
      Functional Food, Fujian Provincial Engineering Technology Research Center of 
      Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation 
      and Utilization of Marine Biological Resources, Jimei University , 43 Yindou 
      Road, Xiamen 361021, Fujian, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20171128
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (IL4 protein, human)
RN  - 0 (Organic Chemicals)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
SB  - IM
MH  - Actinobacteria/*chemistry/*metabolism
MH  - Animals
MH  - Anti-Allergic Agents/metabolism/pharmacology
MH  - Apoptosis
MH  - Bone Marrow
MH  - Cell Degranulation
MH  - Cell Line, Tumor
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/*metabolism
MH  - Interleukin-4/metabolism
MH  - Leukemia, Basophilic, Acute/drug therapy
MH  - Magnetic Resonance Spectroscopy/methods
MH  - Mast Cells
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Organic Chemicals/chemistry/isolation & purification/*metabolism
MH  - Passive Cutaneous Anaphylaxis/*drug effects
MH  - Rats
MH  - Tumor Necrosis Factor-alpha
MH  - beta-N-Acetylhexosaminidases/metabolism
OTO - NOTNLM
OT  - BMMCs
OT  - RBL-2H3
OT  - antiallergy
OT  - apoptosis of mast cells
OT  - deep-sea-derived compounds
OT  - passive cutaneous anaphylaxis
EDAT- 2017/11/18 06:00
MHDA- 2018/11/13 06:00
CRDT- 2017/11/18 06:00
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2018/11/13 06:00 [medline]
PHST- 2017/11/18 06:00 [entrez]
AID - 10.1021/acs.jafc.7b04314 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2017 Dec 13;65(49):10749-10756. doi: 10.1021/acs.jafc.7b04314. 
      Epub 2017 Nov 28.