PMID- 29149345
OWN - NLM
STAT- MEDLINE
DCOM- 20191007
LR  - 20220321
IS  - 1465-3664 (Electronic)
IS  - 0142-6338 (Linking)
VI  - 64
IP  - 5
DP  - 2018 Oct 1
TI  - Predictive Indicators to Identify High-Risk Paediatric Febrile Neutropenia in 
      Paediatric Oncology Patients in a Middle-Income Country.
PG  - 395-402
LID - 10.1093/tropej/fmx082 [doi]
AB  - PURPOSE: To validate a clinical risk prediction score (Ammann score) to predict 
      adverse events (AEs) in paediatric febrile neutropenia (FN). PATIENTS AND 
      METHODS: Patients <16 years of age were enrolled. A risk prediction score (based 
      on haemoglobin >/= 9 g/dl, white cell count (WCC) < 0.3 G/l, platelet count <50 G/l 
      and chemotherapy more intensive than acute lymphoblastic leukaemia maintenance 
      therapy) was calculated and AEs were documented. RESULTS: In total, 100 FN 
      episodes occurred in 52 patients, male:female ratio was 1.8:1 and median age was 
      56 months. At reassessment, AEs occurred in 18 of 55 (45%) low-risk FN episodes 
      (score < 9) and 21 of 42 (55%) high-risk episodes (score >/=9) (sensitivity 60%, 
      specificity 65%, positive predictive value 53%, negative predictive value 71%). 
      Total WCC and absolute monocyte count (AMC) were significantly associated with 
      AEs. CONCLUSION: This study identified total WCC and AMC as significantly 
      associated with AEs but failed to validate the risk prediction score.
FAU - Green, Lindy-Lee
AU  - Green LL
AD  - Paediatric Oncology Unit, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, 
      Francie van Zijl Drive, Tygerberg, Cape Town, South Africa.
FAU - Goussard, Pierre
AU  - Goussard P
AD  - Paediatric Oncology Unit, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, 
      Francie van Zijl Drive, Tygerberg, Cape Town, South Africa.
FAU - van Zyl, Anel
AU  - van Zyl A
AD  - Paediatric Oncology Unit, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, 
      Francie van Zijl Drive, Tygerberg, Cape Town, South Africa.
FAU - Kidd, Martin
AU  - Kidd M
AD  - Centre for Statistical Consultation, Department of Statistics and Actuarial 
      Sciences, University of Stellenbosch, Van der Stel building, Bosman Road 
      Stellenbosch, Private Bag X1, Matieland, Stellenbosch, South Africa.
FAU - Kruger, Mariana
AU  - Kruger M
AD  - Paediatric Oncology Unit, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, 
      Francie van Zijl Drive, Tygerberg, Cape Town, South Africa.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Trop Pediatr
JT  - Journal of tropical pediatrics
JID - 8010948
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Antineoplastic Agents/*adverse effects
MH  - Chemotherapy-Induced Febrile Neutropenia/complications
MH  - Child
MH  - Child, Preschool
MH  - Febrile Neutropenia/blood/*chemically induced/complications
MH  - Female
MH  - Fever/blood/*chemically induced/complications
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Male
MH  - Neoplasms/complications/*drug therapy
MH  - Platelet Count
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2017/11/18 06:00
MHDA- 2019/10/08 06:00
CRDT- 2017/11/18 06:00
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2019/10/08 06:00 [medline]
PHST- 2017/11/18 06:00 [entrez]
AID - 4633655 [pii]
AID - 10.1093/tropej/fmx082 [doi]
PST - ppublish
SO  - J Trop Pediatr. 2018 Oct 1;64(5):395-402. doi: 10.1093/tropej/fmx082.