PMID- 29149780
OWN - NLM
STAT- MEDLINE
DCOM- 20190709
LR  - 20190709
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 16
IP  - 5
DP  - 2017 Oct
TI  - Interleukin-37 Relieves Allergic Inflammation in a House Dust Mite Allergic 
      Rhinitis Murine Model.
PG  - 404-417
AB  - The purpose of this study was to investigate the effects of interleukin-37 
      (IL-37) on a Dermatophagoides farinae (Der f)-induced murine model of allergic 
      rhinitis (AR). BALB/c mice, except the control groups, were sensitized 
      intraperitoneally and challenged intranasally with Der f (Der f group). The IL-37 
      and IL-37+anti-CD25 groups were administered IL-37 intranasally. The 
      IL-37+anti-CD25 groups were administered anti-CD25 monoclonal antibody 
      intraperitoneally before challenge. Allergic symptoms and the average eosinophil 
      number were counted. The levels of cytokines and transcription factors in the 
      nasal mucosa were measured by Real-Time polymerase chain reaction (PCR) and 
      western blotting. The levels of Der f-specific immunoglobulin E (IgE) were 
      measured. The CD4+CD25+Foxp3+T cells among splenic mononuclear cells were 
      analyzed by flow cytometry. The allergic symptom scores and Der f-specific IgE 
      levels were lower in the IL-37 group compared to the Der f group. Additionally, 
      the levels of the transcription factor GATA-3 and ROR-gammat and those of the 
      cytokines IL-4, IL-5, IL-13, and IL-17, representing both T helper (Th)2 and Th17 
      responses, were lower in the IL-37 group in comparison with the Der f group. 
      However, the Th1 responsewas not suppressed after administration of IL-37. IL-37 
      increased the IL-10 level; however, Real-Time PCR, western blotting, and flow 
      cytometry results showed the limited action of IL-37 on CD4+CD25+Foxp3+T cells. 
      This study demonstrates that intranasal IL-37 can suppress Th2 and Th17 responses 
      in an AR murine model. Furthermore, these data suggest that IL-10 is increased, 
      but CD4+CD25+Foxp3+T cells are not correlated with the IL-37-induced mechanism.
FAU - Kim, Do Hyun
AU  - Kim DH
AD  - Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kim, Si Won
AU  - Kim SW
AD  - Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kim, Soo Whan
AU  - Kim SW
AD  - Department of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kang, Jun-Myung
AU  - Kang JM
AD  - Department of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Il1f10 protein, mouse)
RN  - 0 (Interleukin-1)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Antibody Specificity/immunology
MH  - Antigens, Dermatophagoides/immunology
MH  - Biomarkers
MH  - Cytokines/biosynthesis
MH  - Dermatophagoides farinae/*immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Immunoglobulin E/blood/immunology
MH  - Immunophenotyping
MH  - Interleukin-1/*metabolism/pharmacology
MH  - Mice
MH  - Nasal Mucosa/immunology/metabolism/pathology
MH  - Rhinitis, Allergic/*immunology/*metabolism/pathology/therapy
MH  - T-Lymphocyte Subsets/drug effects/immunology/metabolism
OTO - NOTNLM
OT  - Allergy
OT  - Dermatophagoides farinae
OT  - Mice
OT  - Regulatory
OT  - Rhinitis
OT  - T Lymphocytes
EDAT- 2017/11/19 06:00
MHDA- 2019/07/10 06:00
CRDT- 2017/11/19 06:00
PHST- 2017/10/28 00:00 [accepted]
PHST- 2017/11/19 06:00 [entrez]
PHST- 2017/11/19 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
PST - ppublish
SO  - Iran J Allergy Asthma Immunol. 2017 Oct;16(5):404-417.