PMID- 29149991
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180131
LR  - 20180131
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 997
DP  - 2018 Jan 2
TI  - A fast and low-cost microfabrication approach for six types of thermoplastic 
      substrates with reduced feature size and minimized bulges using sacrificial layer 
      assisted laser engraving.
PG  - 24-34
LID - S0003-2670(17)31189-3 [pii]
LID - 10.1016/j.aca.2017.10.030 [doi]
AB  - Since polydimethylsiloxane (PDMS) is notorious for its severe sorption to 
      biological compounds and even nanoparticles, thermoplastics become a promising 
      substrate for microdevices. Although CO(2) laser engraving is an efficient method 
      for thermoplastic device fabrication, it accompanies with poor bonding issues due 
      to severe bulging and large feature size determined by the diameter of laser 
      beam. In this study, a low-cost microfabrication method is proposed by reversibly 
      sealing a 1 mm thick polymethylmethacrylate (PMMA) over an engraving substrate to 
      reduce channel feature size and minimize bulges of laser engraved channels. PMMA, 
      polycarbonate (PC), polystyrene (PS), perfluoroalkoxy alkane (PFA), cyclic-olefin 
      polymers (COP) and polylactic acid (PLA) were found compatible with this 
      sacrificial layer assisted laser engraving technique. Microchannel width as small 
      as  approximately 40 mum was attainable by a laser beam that was 5 times larger in diameter. 
      Bulging height was significantly reduced to less 5 mum for most substrates, which 
      facilitated leak proof device bonding without channel deformation. Microdevices 
      with high aspect ratio channels were prepared to demonstrate the applicability of 
      this microfabrication method. We believe this fast and low-cost fabrication 
      approach for thermoplastics will be of interest to researchers who have 
      encountered problem with polydimethylsiloxane based microdevices in their 
      applications.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Gu, Longjun
AU  - Gu L
AD  - Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.
FAU - Yu, Guodong
AU  - Yu G
AD  - Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.
FAU - Li, Cheuk-Wing
AU  - Li CW
AD  - Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China. 
      Electronic address: cheukwli@umac.mo.
LA  - eng
PT  - Journal Article
DEP - 20171027
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
OTO - NOTNLM
OT  - CO(2) laser
OT  - High aspect ratio
OT  - Minimized bulge height
OT  - Reduced feature size
OT  - Sacrificial layer
OT  - Thermoplastics
EDAT- 2017/11/19 06:00
MHDA- 2017/11/19 06:01
CRDT- 2017/11/19 06:00
PHST- 2017/04/20 00:00 [received]
PHST- 2017/10/18 00:00 [revised]
PHST- 2017/10/23 00:00 [accepted]
PHST- 2017/11/19 06:00 [entrez]
PHST- 2017/11/19 06:00 [pubmed]
PHST- 2017/11/19 06:01 [medline]
AID - S0003-2670(17)31189-3 [pii]
AID - 10.1016/j.aca.2017.10.030 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2018 Jan 2;997:24-34. doi: 10.1016/j.aca.2017.10.030. Epub 2017 
      Oct 27.