PMID- 29150155
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20180723
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 27
IP  - 3
DP  - 2018 Mar
TI  - The Association of Functional Capacity With Right Atrial Deformation in Patients 
      With Pulmonary Arterial Hypertension: A Study With Two-Dimensional Speckle 
      Tracking.
PG  - 350-358
LID - S1443-9506(17)30290-1 [pii]
LID - 10.1016/j.hlc.2017.02.029 [doi]
AB  - BACKGROUND: The purpose of this study was to assess right atrial (RA) myocardial 
      mechanics in pulmonary hypertension (PH) patients using two-dimensional speckle 
      tracking (2D-STE), and define the relationship between RA function and exercise 
      capacity in PH patients. METHODS: Thirty-eight consecutive PH patients were 
      studied and compared with a control group of 25 healthy volunteers. Peak atrial 
      longitudinal strain (PALS), RA strain rate were measured in all subjects. PALS 
      values were obtained by averaging all segments (global PALS), and by averaging 
      segments measured in the four-chamber view. RESULTS: Right atrial PALS was 
      significantly lower in PH patients than in controls, and gradually reduced with 
      the development of cardiac insufficiency. A significantly positive correlation 
      between global PALS and 6-minute walk distance (6MWD) was found (p=0.003). 
      Furthermore, global PALS demonstrated the highest diagnostic accuracy (AUC of 
      0.979) and excellent sensitivity and specificity of 86.8% and 84%, respectively, 
      to predict functional status using a cut-off value less than 38.08%. CONCLUSIONS: 
      Right atrial deformation is significantly damaged in PH patients. Right atrial 
      reservoir function can be estimated using 2D-STE, which gradually decreases in PH 
      patients with different World Health Organization-functional class (WHO-FC). 
      Right atrial PALS is a valuable factor for predicting the functional status and 
      exercise capacity in PH patients.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Liu, Weiwei
AU  - Liu W
AD  - Department of Cardiac Ultrasound, The Second Hospital of Hebei Medical 
      University, China.
FAU - Wang, Yueheng
AU  - Wang Y
AD  - Department of Cardiac Ultrasound, The Second Hospital of Hebei Medical 
      University, China. Electronic address: wyhucg@sina.com.
FAU - Zhou, Jinling
AU  - Zhou J
AD  - Department of Cardiac Ultrasound, The Second Hospital of Hebei Medical 
      University, China.
FAU - Bai, Hui
AU  - Bai H
AD  - Department of Cardiac Ultrasound, The Second Hospital of Hebei Medical 
      University, China.
FAU - Wang, Feng
AU  - Wang F
AD  - Department of Cardiac Ultrasound, The Second Hospital of Hebei Medical 
      University, China.
FAU - Wang, Ju
AU  - Wang J
AD  - Department of Cardiac Ultrasound, The Second Hospital of Hebei Medical 
      University, China.
LA  - eng
PT  - Journal Article
DEP - 20170413
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
SB  - IM
MH  - Adult
MH  - Atrial Function, Right/*physiology
MH  - Echocardiography/*methods
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Atria/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Hypertension, Pulmonary/diagnosis/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Motor Activity/*physiology
MH  - ROC Curve
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Longitudinal strain
OT  - Pulmonary hypertension
OT  - Right atrium
OT  - Speckle-tracking echocardiography
EDAT- 2017/11/19 06:00
MHDA- 2018/07/24 06:00
CRDT- 2017/11/19 06:00
PHST- 2016/04/17 00:00 [received]
PHST- 2017/01/03 00:00 [revised]
PHST- 2017/02/15 00:00 [accepted]
PHST- 2017/11/19 06:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PHST- 2017/11/19 06:00 [entrez]
AID - S1443-9506(17)30290-1 [pii]
AID - 10.1016/j.hlc.2017.02.029 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2018 Mar;27(3):350-358. doi: 10.1016/j.hlc.2017.02.029. Epub 
      2017 Apr 13.