PMID- 29151117
OWN - NLM
STAT- MEDLINE
DCOM- 20180809
LR  - 20181113
IS  - 2194-7236 (Electronic)
IS  - 2194-7228 (Linking)
VI  - 46
IP  - 1
DP  - 2018 Feb
TI  - Risks of flexible ureterorenoscopy: pathophysiology and prevention.
PG  - 59-67
LID - 10.1007/s00240-017-1018-6 [doi]
AB  - Currently, indications for flexible ureterorenoscopy (fURS) are expanding, mainly 
      due to technological advancements. Although data from clinical series definitely 
      presents fURS as a safe procedure, serious complications including sepsis and 
      ureteral lesions do occur. These complications seem to be a result of the unique 
      elements of fURS, ureteral access and irrigation, pushing normal upper urinary 
      tract physiology into pathophysiological processes, including 
      intrarenal/pyelo-veneous backflow and ureteral contractions, potentially 
      resulting in septic, haemorrhagic and ureteral lesional complications. Knowledge 
      on normal upper urinary tract physiology are crucial for understanding how these 
      harmful effects of fURS may be avoided or minimized. The pathophysiology of 
      intrarenal pressure increases and ureteral access will be discussed as a basis 
      for understanding preventive measures. Role of antibiotics, ureteral access 
      sheaths, safty guidewires, pain medication, prestenting and pharmacologic 
      modulation of pyeloureteral dynamics are reviewed from a pathophysiological 
      perspective.
FAU - Osther, Palle J S
AU  - Osther PJS
AUID- ORCID: 0000-0001-7962-1640
AD  - Urological Research Center, Department of Urology, Lillebaelt Hospital, 
      Beridderbakken 4, 7100, Vejle, Denmark. palle.joern.osther@rsyd.dk.
AD  - Department of Regional Health Research, Faculty of Health Sciences, University of 
      Southern Denmark, Vejle, Denmark. palle.joern.osther@rsyd.dk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171118
PL  - Germany
TA  - Urolithiasis
JT  - Urolithiasis
JID - 101602699
SB  - IM
MH  - Equipment Design
MH  - Humans
MH  - Kidney/physiopathology
MH  - Kidney Calculi/*physiopathology/*surgery
MH  - Postoperative Complications/etiology/*prevention & control
MH  - Risk Factors
MH  - Ureter/physiopathology
MH  - Ureteral Calculi/*physiopathology/*surgery
MH  - Ureteroscopes/*adverse effects
MH  - Ureteroscopy/*adverse effects/methods
OTO - NOTNLM
OT  - Complications
OT  - Intrarenal pressure
OT  - Pathophysiology
OT  - Prevention
OT  - Ureteral access sheath
OT  - Ureterorenoscopy
EDAT- 2017/11/21 06:00
MHDA- 2018/08/10 06:00
CRDT- 2017/11/20 06:00
PHST- 2017/10/11 00:00 [received]
PHST- 2017/11/11 00:00 [accepted]
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2018/08/10 06:00 [medline]
PHST- 2017/11/20 06:00 [entrez]
AID - 10.1007/s00240-017-1018-6 [pii]
AID - 10.1007/s00240-017-1018-6 [doi]
PST - ppublish
SO  - Urolithiasis. 2018 Feb;46(1):59-67. doi: 10.1007/s00240-017-1018-6. Epub 2017 Nov 
      18.