PMID- 29151487
OWN - NLM
STAT- MEDLINE
DCOM- 20171218
LR  - 20171218
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 58
IP  - 6
DP  - 2017 Dec 12
TI  - Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease 
      in Patients with ST Elevation Myocardial Infarction.
PG  - 868-873
LID - 10.1536/ihj.16-565 [doi]
AB  - A relationship between serum polyunsaturated fatty acids (PUFAs) and 
      cardiovascular disease has been reported; however, the existence of a 
      relationship between serum PUFAs and extent of vessel disease (VD) in patients 
      with ST elevation myocardial infarction (STEMI) remains unclear.Between July 2011 
      and June 2015, 866 consecutive STEMI patients underwent emergent percutaneous 
      coronary intervention, 507 of whom were enrolled and classified into three groups 
      according to the initial angiograms: 1VD, 294 patients; 2VD, 110 patients; and 
      3VD/left main trunk disease (LMTD), 103 patients. Serum levels of PUFAs, 
      including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and 
      arachidonic acid, and other laboratory data during hospitalization were 
      evaluated.The serum EPA level in the 3VD/LMTD group was significantly lower than 
      that in the 1VD group (55.5 +/- 22.1 versus 66.2 +/- 28.7, P = 0.002) and was 
      slightly lower than that in the 2VD group (55.5 +/- 22.1 versus 65.2 +/- 28.9, P = 
      0.0167). Multivariate adjustment analysis revealed that age >/= 70 years (odds 
      ratio, 1.72; 95% confidence interval, 1.03-2.89; P = 0.038) and a low serum EPA 
      level (odds ratio, 0.98; 95% confidence interval, 0.99-1.00; P = 0.023) were 
      independent risk factors for 3VD/LMTD, while a low serum DHA level was not.A low 
      serum EPA level may be more strongly related than a low serum DHA level to the 
      extent of VD in STEMI patients. Age >/= 70 years and a low serum EPA level may be 
      independent risk factors for 3VD/LMTD.
FAU - Shimada, Takenobu
AU  - Shimada T
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Kadota, Kazushige
AU  - Kadota K
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Eguchi, Haruki
AU  - Eguchi H
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Osakada, Kohei
AU  - Osakada K
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Kuwayama, Akimune
AU  - Kuwayama A
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Ohya, Masanobu
AU  - Ohya M
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Miura, Katsuya
AU  - Miura K
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Amano, Hidewo
AU  - Amano H
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Kubo, Shunsuke
AU  - Kubo S
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Ozaki, Masatomo
AU  - Ozaki M
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Hyodo, Yusuke
AU  - Hyodo Y
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Yoshino, Mitsuru
AU  - Yoshino M
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Miyake, Koshi
AU  - Miyake K
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Kawase, Yuichi
AU  - Kawase Y
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Ohashi, Noriyuki
AU  - Ohashi N
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Otsuru, Suguru
AU  - Otsuru S
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Tasaka, Hiroshi
AU  - Tasaka H
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Habara, Seiji
AU  - Habara S
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Tada, Takeshi
AU  - Tada T
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Tanaka, Hiroyuki
AU  - Tanaka H
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Maruo, Takeshi
AU  - Maruo T
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Fuku, Yasushi
AU  - Fuku Y
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Katoh, Harumi
AU  - Katoh H
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Fujii, Satoki
AU  - Fujii S
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Goto, Tsuyoshi
AU  - Goto T
AD  - Department of Cardiology, Kurashiki Central Hospital.
FAU - Mitsudo, Kazuaki
AU  - Mitsudo K
AD  - Department of Cardiology, Kurashiki Central Hospital.
LA  - eng
PT  - Journal Article
DEP - 20171117
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
RN  - 0 (Biomarkers)
RN  - 0 (Fatty Acids, Omega-3)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*blood/complications/diagnostic imaging
MH  - Coronary Vessels/*diagnostic imaging
MH  - Cross-Sectional Studies
MH  - Fatty Acids, Omega-3/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention
MH  - ST Elevation Myocardial Infarction/*blood/complications/therapy
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Cardiovascular disease
OT  - Docosahexaenoic acid
OT  - Eicosapentaenoic acid
OT  - Mulivessel disease
EDAT- 2017/11/21 06:00
MHDA- 2017/12/19 06:00
CRDT- 2017/11/21 06:00
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2017/12/19 06:00 [medline]
PHST- 2017/11/21 06:00 [entrez]
AID - 10.1536/ihj.16-565 [doi]
PST - ppublish
SO  - Int Heart J. 2017 Dec 12;58(6):868-873. doi: 10.1536/ihj.16-565. Epub 2017 Nov 
      17.