PMID- 29151503
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20181202
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 57
IP  - 4
DP  - 2018 Feb 15
TI  - Acute Megakaryoblastic Leukemia Developing as Donor Cell Leukemia after Umbilical 
      Cord Blood Transplantation.
PG  - 569-574
LID - 10.2169/internalmedicine.9005-17 [doi]
AB  - A 64-year-old man with acute myeloid leukemia underwent umbilical cord blood 
      transplantation (UCBT). After 11 months of complete remission (CR) following 
      UCBT, the bone marrow showed 7.5% myeloblasts. CR was obtained after a single 
      course of azacitidine monotherapy, but the myeloblasts gradually increased in the 
      blood. We made a diagnosis of acute megakaryoblastic leukemia derived from donor 
      cell with a fluorescence in situ hybridization (FISH) analysis of the sex 
      chromosomes and an immunophenotypic analysis. Azacitidine was administered again 
      and produced a therapeutic effect of stable disease. This case suggests that 
      azacitidine may be a useful therapy for patients with acute megakaryoblastic 
      leukemia in situations in which intensive chemotherapy and transplantation are 
      not indicated.
FAU - Adachi, Yoshitaka
AU  - Adachi Y
AD  - Department of Hematology and Oncology, Konan Kosei Hospital, Japan.
FAU - Yamaguchi, Yohei
AU  - Yamaguchi Y
AD  - Department of Hematology and Oncology, Japanese Red Cross Nagoya Daini Hospital, 
      Japan.
FAU - Sagou, Ken
AU  - Sagou K
AD  - Department of Hematology and Oncology, Konan Kosei Hospital, Japan.
FAU - Yamaga, Yusuke
AU  - Yamaga Y
AD  - Department of Hematology and Oncology, Konan Kosei Hospital, Japan.
FAU - Fukushima, Nobuaki
AU  - Fukushima N
AD  - Department of Hematology and Oncology, Konan Kosei Hospital, Japan.
FAU - Ozeki, Kazutaka
AU  - Ozeki K
AD  - Department of Hematology and Oncology, Konan Kosei Hospital, Japan.
FAU - Kohno, Akio
AU  - Kohno A
AD  - Department of Hematology and Oncology, Konan Kosei Hospital, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20171120
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
MH  - Cord Blood Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Leukemia, Megakaryoblastic, Acute/diagnosis/*etiology
MH  - Leukemia, Myeloid, Acute/*therapy
MH  - Male
MH  - Middle Aged
PMC - PMC5849555
OTO - NOTNLM
OT  - acute megakaryoblastic leukemia
OT  - azacitidine
OT  - donor cell leukemia
OT  - umbilical cord blood transplantation
EDAT- 2017/11/21 06:00
MHDA- 2018/07/17 06:00
PMCR- 2018/02/15
CRDT- 2017/11/21 06:00
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2017/11/21 06:00 [entrez]
PHST- 2018/02/15 00:00 [pmc-release]
AID - 10.2169/internalmedicine.9005-17 [doi]
PST - ppublish
SO  - Intern Med. 2018 Feb 15;57(4):569-574. doi: 10.2169/internalmedicine.9005-17. 
      Epub 2017 Nov 20.