PMID- 29151505
OWN - NLM
STAT- MEDLINE
DCOM- 20180725
LR  - 20221207
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 57
IP  - 4
DP  - 2018 Feb 15
TI  - Isolated Adrenocorticotropin Deficiency due to Nivolumab-induced Hypophysitis in 
      a Patient with Advanced Lung Adenocarcinoma: A Case Report and Literature Review.
PG  - 527-535
LID - 10.2169/internalmedicine.9074-17 [doi]
AB  - A 63-year-old Japanese woman with advanced lung adenocarcinoma developed isolated 
      adrenocorticotropin deficiency caused by immune checkpoint inhibitor 
      (ICI)-related hypophysitis following 8 months of nivolumab therapy. Prompt 
      corticosteroid replacement therapy effectively relieved her secondary adrenal 
      insufficiency symptoms and allowed her to pursue nivolumab therapy, which had 
      been effective for the control of lung adenocarcinoma. Human leukocyte antigen 
      (HLA) typing revealed the presence of the DRB1*04:05-DQA1*03:03-DQB1*04:01 
      haplotype, which is associated with susceptibility to autoimmune polyglandular 
      syndrome with pituitary disorder in the Japanese population. This case suggests 
      that genetic factors, such as HLA, contribute to the development of 
      endocrinopathies induced by ICIs.
FAU - Ohara, Nobumasa
AU  - Ohara N
AD  - Department of Endocrinology and Metabolism, Uonuma Institute of Community 
      Medicine, Niigata University Medical and Dental Hospital, Japan.
FAU - Ohashi, Kazumasa
AU  - Ohashi K
AD  - Department of Respiratory Medicine, Uonuma Institute of Community Medicine, 
      Niigata University Medical and Dental Hospital, Japan.
FAU - Fujisaki, Toshiya
AU  - Fujisaki T
AD  - Department of Respiratory Medicine, Uonuma Institute of Community Medicine, 
      Niigata University Medical and Dental Hospital, Japan.
FAU - Oda, Chiyumi
AU  - Oda C
AD  - Department of Endocrinology and Metabolism, Uonuma Institute of Community 
      Medicine, Niigata University Medical and Dental Hospital, Japan.
FAU - Ikeda, Yohei
AU  - Ikeda Y
AD  - Department of Radiology, Uonuma Institute of Community Medicine, Niigata 
      University Medical and Dental Hospital, Japan.
FAU - Yoneoka, Yuichiro
AU  - Yoneoka Y
AD  - Department of Neurosurgery, Uonuma Institute of Community Medicine, Niigata 
      University Medical and Dental Hospital, Japan.
FAU - Hashimoto, Takehisa
AU  - Hashimoto T
AD  - Department of Thoracic Surgery, Uonuma Institute of Community Medicine, Niigata 
      University Medical and Dental Hospital, Japan.
FAU - Hasegawa, Go
AU  - Hasegawa G
AD  - Department of Pathology, Uonuma Institute of Community Medicine, Niigata 
      University Medical and Dental Hospital, Japan.
FAU - Suzuki, Kazuo
AU  - Suzuki K
AD  - Department of Respiratory Medicine, Uonuma Institute of Community Medicine, 
      Niigata University Medical and Dental Hospital, Japan.
FAU - Takada, Toshinori
AU  - Takada T
AD  - Department of Respiratory Medicine, Uonuma Institute of Community Medicine, 
      Niigata University Medical and Dental Hospital, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20171120
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antineoplastic Agents)
RN  - 31YO63LBSN (Nivolumab)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adenocarcinoma/*drug therapy
MH  - Adenocarcinoma of Lung
MH  - Adrenal Cortex Hormones/*therapeutic use
MH  - Adrenocorticotropic Hormone/*deficiency
MH  - Antibodies, Monoclonal/*adverse effects/therapeutic use
MH  - Antineoplastic Agents/*adverse effects/therapeutic use
MH  - Asian People
MH  - Female
MH  - Humans
MH  - Hypophysitis/*chemically induced/*drug therapy
MH  - Lung Neoplasms/*drug therapy
MH  - Middle Aged
MH  - Nivolumab
PMC - PMC5849549
OTO - NOTNLM
OT  - human leukocyte antigen
OT  - hydrocortisone
OT  - hypophysitis
OT  - lung adenocarcinoma
OT  - nivolumab
EDAT- 2017/11/21 06:00
MHDA- 2018/07/26 06:00
PMCR- 2018/02/15
CRDT- 2017/11/21 06:00
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2018/07/26 06:00 [medline]
PHST- 2017/11/21 06:00 [entrez]
PHST- 2018/02/15 00:00 [pmc-release]
AID - 10.2169/internalmedicine.9074-17 [doi]
PST - ppublish
SO  - Intern Med. 2018 Feb 15;57(4):527-535. doi: 10.2169/internalmedicine.9074-17. 
      Epub 2017 Nov 20.