PMID- 29152239
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2048-6790 (Print)
IS  - 2048-6790 (Electronic)
IS  - 2048-6790 (Linking)
VI  - 6
DP  - 2017
TI  - Effects of dietary supplementation with a mixed blueberry and grape extract on 
      working memory in aged beagle dogs.
PG  - e35
LID - 10.1017/jns.2017.33 [doi]
LID - e35
AB  - Cellular oxidative damage is thought to be one of the key mechanisms underlying 
      age-related cognitive impairment in dogs. Several nutritional interventions to 
      limit cognitive decline are reported in the literature. To our knowledge, the 
      association of grape and blueberry extracts has never been tested in aged dogs. 
      Our objective was to evaluate the effect of a polyphenol-rich extract from grape 
      and blueberry (PEGB) on oxidative status and cognitive performances in aged dogs. 
      A total of thirty-five beagle dogs (aged 8.0-14.5 years) were fed a basal diet 
      with PEGB at either 0 parts per million (ppm) (n 11; control), 240 ppm (n 12; 
      PEGB1) or 480 ppm (n 12; PEGB2) for 75 d. To investigate the effects of PEGB 
      supplementation on cognition and oxidative status, a delayed non-matching to 
      position (DNMP) test and RT-PCR on genes involved in oxidative stress were 
      evaluated. The dogs fed PEGB1 showed a higher superoxide dismutase mRNA 
      expression compared with dogs fed PEGB2 (P = 0.042) and with the control group 
      (P = 0.014). Moreover, the dogs fed PEGB2 showed higher nuclear factor-like 2 
      (Nrf2) mRNA expression compared with the dogs fed PEGB1 (P = 0.027). Concerning 
      the DNMP test, the proportion of dogs showing cognitive improvements relative to 
      their baseline level was significantly higher in dogs fed the PEGB, regardless of 
      the dosage, than in dogs receiving no supplementation (P = 0.030). The results 
      obtained in the DNMP test suggested a potential benefit of the PEGB on working 
      memory. However, this hypothesis should be further investigated to confirm this 
      cognitive effect.
FAU - Fragua, V
AU  - Fragua V
AD  - Diana Pet Food, Elven, France.
FAU - Lepoudere, A
AU  - Lepoudere A
AD  - Diana Pet Food, Elven, France.
FAU - Leray, V
AU  - Leray V
AD  - Oniris, National College of Veterinary Medicine, Food Science and Engineering, 
      Nantes, France.
FAU - Baron, C
AU  - Baron C
AD  - Diana Pet Food, Elven, France.
FAU - Araujo, J A
AU  - Araujo JA
AD  - CanCog Technologies, Toronto, Canada.
AD  - InterVivo Solutions Inc., Toronto, Canada.
FAU - Nguyen, P
AU  - Nguyen P
AD  - Oniris, National College of Veterinary Medicine, Food Science and Engineering, 
      Nantes, France.
FAU - Milgram, N W
AU  - Milgram NW
AD  - CanCog Technologies, Toronto, Canada.
LA  - eng
PT  - Journal Article
DEP - 20170712
PL  - England
TA  - J Nutr Sci
JT  - Journal of nutritional science
JID - 101590587
PMC - PMC5672304
OTO - NOTNLM
OT  - Aged dogs
OT  - Blueberries
OT  - CDS, cognitive dysfunction syndrome
OT  - Cognition
OT  - Cognitive decline
OT  - DNMP, delayed non-matching to position
OT  - Grape extract
OT  - Oxidative status
OT  - PEGB, polyphenol-rich extract from grape and blueberry
OT  - PEGB1, PEGB at 240 parts per million
OT  - PEGB2, PEGB at 480 parts per million
OT  - Polyphenols
EDAT- 2017/11/21 06:00
MHDA- 2017/11/21 06:01
PMCR- 2017/11/06
CRDT- 2017/11/21 06:00
PHST- 2016/11/14 00:00 [received]
PHST- 2017/05/12 00:00 [revised]
PHST- 2017/06/16 00:00 [accepted]
PHST- 2017/11/21 06:00 [entrez]
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2017/11/21 06:01 [medline]
PHST- 2017/11/06 00:00 [pmc-release]
AID - 00033 [pii]
AID - 10.1017/jns.2017.33 [doi]
PST - epublish
SO  - J Nutr Sci. 2017 Jul 12;6:e35. doi: 10.1017/jns.2017.33. eCollection 2017.