PMID- 29153447 OWN - NLM STAT- MEDLINE DCOM- 20191108 LR - 20191108 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 197 DP - 2018 Jul TI - Abnormal brain activation during threatening face processing in schizophrenia: A meta-analysis of functional neuroimaging studies. PG - 200-208 LID - S0920-9964(17)30708-9 [pii] LID - 10.1016/j.schres.2017.11.013 [doi] AB - Impairment of face perception in schizophrenia is a core aspect of social cognitive dysfunction. This impairment is particularly marked in threatening face processing. Identifying reliable neural correlates of the impairment of threatening face processing is crucial for targeting more effective treatments. However, neuroimaging studies have not yet obtained robust conclusions. Through comprehensive literature search, twenty-one whole brain datasets were included in this meta-analysis. Using seed-based d-Mapping, in this voxel-based meta-analysis, we aimed to: 1) establish the most consistent brain dysfunctions related to threating face processing in schizophrenia; 2) address task-type heterogeneity in this impairment; 3) explore the effect of potential demographic or clinical moderator variables on this impairment. Main meta-analysis indicated that patients with chronic schizophrenia demonstrated attenuated activations in limbic emotional system along with compensatory over-activation in medial prefrontal cortex (MPFC) during threatening faces processing. Sub-task analyses revealed under-activations in right amygdala and left fusiform gyrus in both implicit and explicit tasks. The remaining clusters were found to be differently involved in different types of tasks. Moreover, meta-regression analyses showed brain abnormalities in schizophrenia were partly modulated by age, gender, medication and severity of symptoms. Our results highlighted breakdowns in limbic-MPFC circuit in schizophrenia, suggesting general inability to coordinate and contextualize salient threat stimuli. These findings provide potential targets for neurotherapeutic and pharmacological interventions for schizophrenia. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Dong, Debo AU - Dong D AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, Chengdu 611731, China. Electronic address: debo.dong@gmail.com. FAU - Wang, Yulin AU - Wang Y AD - Faculty of Psychological and Educational Sciences, Department of Experimental and Applied Psychology, Research Group of Biological Psychology, Vrije Universiteit Brussel, Brussels 1040, Belgium; Department of Data Analysis, Faculty of Psychological and Pedagogical Sciences, Ghent University, Henri Dunantlaan 1, B-9000 Gent, Belgium. Electronic address: wang.yulin@vub.ac.be. FAU - Jia, Xiaoyan AU - Jia X AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, Chengdu 611731, China. Electronic address: jiaxiaoyan_0919@163.com. FAU - Li, Yingjia AU - Li Y AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, Chengdu 611731, China. Electronic address: yingjiali22@163.com. FAU - Chang, Xuebin AU - Chang X AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, Chengdu 611731, China. Electronic address: XuebinChang@163.com. FAU - Vandekerckhove, Marie AU - Vandekerckhove M AD - Faculty of Psychological and Educational Sciences, Department of Experimental and Applied Psychology, Research Group of Biological Psychology, Vrije Universiteit Brussel, Brussels 1040, Belgium. Electronic address: Marie.vandekerckhove@vub.ac.be. FAU - Luo, Cheng AU - Luo C AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, Chengdu 611731, China. Electronic address: chengluo@uestc.edu.cn. FAU - Yao, Dezhong AU - Yao D AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, Chengdu 611731, China. Electronic address: dyao@uestc.edu.cn. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't DEP - 20171115 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adult MH - Cognitive Dysfunction/diagnostic imaging/etiology/*physiopathology MH - *Facial Expression MH - Facial Recognition/*physiology MH - Fear/*physiology MH - Female MH - *Functional Neuroimaging MH - Humans MH - Limbic System/diagnostic imaging/*physiopathology MH - Male MH - Prefrontal Cortex/diagnostic imaging/*physiopathology MH - Schizophrenia/complications/diagnostic imaging/*physiopathology OTO - NOTNLM OT - Facial perception OT - Limbic-MPFC circuit OT - Meta-analysis OT - Schizophrenia OT - Threat OT - fMRI EDAT- 2017/11/21 06:00 MHDA- 2019/11/09 06:00 CRDT- 2017/11/21 06:00 PHST- 2017/09/06 00:00 [received] PHST- 2017/11/07 00:00 [revised] PHST- 2017/11/09 00:00 [accepted] PHST- 2017/11/21 06:00 [pubmed] PHST- 2019/11/09 06:00 [medline] PHST- 2017/11/21 06:00 [entrez] AID - S0920-9964(17)30708-9 [pii] AID - 10.1016/j.schres.2017.11.013 [doi] PST - ppublish SO - Schizophr Res. 2018 Jul;197:200-208. doi: 10.1016/j.schres.2017.11.013. Epub 2017 Nov 15.