PMID- 29153510
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20180813
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 384
DP  - 2018 Jan 15
TI  - Resumption of antiplatelet therapy in patients with primary intracranial 
      hemorrhage-benefits and risks: A meta-analysis of cohort studies.
PG  - 133-138
LID - S0022-510X(17)34441-6 [pii]
LID - 10.1016/j.jns.2017.11.009 [doi]
AB  - BACKGROUND: Clinical disagreement over antiplatelet (AP) resumption in patients 
      with primary intracranial hemorrhage (ICH) has long existed. This meta-analysis 
      aimed to evaluate the benefits of AP resumption on preventing ischemic or 
      thromboembolic events against its risks of promoting ICH recurrence or hematoma 
      expansion. METHODS: All relevant articles published in Pubmed, EMBASE, the 
      Cochrane Library, and Science Direct from January 1950 to March 2017 were 
      sourced, and the combined relative risk (RR) was calculated. RESULTS: A total of 
      3648 articles were found, and after screening, 6 cohort studies including 1916 
      patients were included in this meta-analysis. AP resumption was associated with a 
      decreased risk of ischemic or thromboembolic events (RR, 0.61; 95% confidence 
      interval (CI), 0.48-0.79; P<0.01). There was no significant difference in the 
      risk of ICH recurrence or hematoma expansion between patients with or without AP 
      resumption (RR, 0.84; 95% CI, 0.47-1.51; P=0.56). CONCLUSION: AP resumption in 
      patients with primary ICH reduced the risk of ischemic or thromboembolic events, 
      without significant increase of risk of ICH recurrence or hematoma expansion.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Ding, Xueying
AU  - Ding X
AD  - Department of Neurology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China.
FAU - Liu, Xi
AU  - Liu X
AD  - Department of Neurology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China.
FAU - Tan, Changhong
AU  - Tan C
AD  - Department of Neurology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China.
FAU - Yin, Maojia
AU  - Yin M
AD  - Department of Neurology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China.
FAU - Wang, Teng
AU  - Wang T
AD  - Department of Neurology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Neurology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China.
FAU - Mo, Lijuan
AU  - Mo L
AD  - Department of Neurology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China.
FAU - Wei, Xin
AU  - Wei X
AD  - Department of Neurology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China.
FAU - Tan, Xinjie
AU  - Tan X
AD  - Department of Neurology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China.
FAU - Deng, Fen
AU  - Deng F
AD  - Department of Neurology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China. Electronic address: dengf1996@126.com.
FAU - Chen, Lifen
AU  - Chen L
AD  - Department of Neurology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China. Electronic address: 
      300273@hospital.cqmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20171110
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - Brain Ischemia/epidemiology/prevention & control
MH  - Humans
MH  - Intracranial Hemorrhages/complications/*epidemiology
MH  - Platelet Aggregation Inhibitors/*adverse effects/*therapeutic use
MH  - Risk
MH  - Thromboembolism/epidemiology/prevention & control
OTO - NOTNLM
OT  - Antiplatelet therapy
OT  - Hematoma expansion
OT  - Intracranial hemorrhage
OT  - Ischemia
OT  - Thromboembolism
EDAT- 2017/11/21 06:00
MHDA- 2018/08/14 06:00
CRDT- 2017/11/21 06:00
PHST- 2017/08/30 00:00 [received]
PHST- 2017/10/18 00:00 [revised]
PHST- 2017/11/08 00:00 [accepted]
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PHST- 2017/11/21 06:00 [entrez]
AID - S0022-510X(17)34441-6 [pii]
AID - 10.1016/j.jns.2017.11.009 [doi]
PST - ppublish
SO  - J Neurol Sci. 2018 Jan 15;384:133-138. doi: 10.1016/j.jns.2017.11.009. Epub 2017 
      Nov 10.