PMID- 29153538
OWN - NLM
STAT- MEDLINE
DCOM- 20181109
LR  - 20181109
IS  - 1876-035X (Electronic)
IS  - 1876-0341 (Linking)
VI  - 11
IP  - 4
DP  - 2018 Jul-Aug
TI  - Oral paracoccidioidomycosis in a single-center retrospective analysis from a 
      Brazilian southeastern population.
PG  - 530-533
LID - S1876-0341(17)30284-8 [pii]
LID - 10.1016/j.jiph.2017.10.009 [doi]
AB  - BACKGROUND: Paracoccidioidomycosis (PCM) is the most prevalent endemic systemic 
      fungal infection in Latin America. In Brazil, it stands out as the eighth-highest 
      cause of mortality among chronic or recurrent infections and has the highest 
      mortality rate among systemic mycoses. Oral mucosal lesions may be the first 
      visible physical manifestation of the disease. This study traced the 
      epidemiological and clinical profiles of patients with oral lesions treated at 
      the University Hospital Cassiano Antonio Moraes, Federal University of Espirito 
      Santo. METHODS: A retrospective cross-sectional analysis of patient medical 
      records was performed. RESULTS: Among the 161 patients identified with a 
      confirmed diagnosis of PCM, 97 (60.24%) presented with oral lesions. The 
      male:female ratio was 15:1, the mean age was 50.5 years, and the chronic form of 
      paracoccidioidomycosis was predominant. Most of the patients had smoking habits 
      and were rural workers. The most common oral lesions present in various 
      anatomical sites were mulberry-like ulcers, more frequently observed in the 
      gingiva, with regression within one to three months. Patients completed the 
      treatment in one to two years (32.99%), and 47.42% of cases discontinued 
      treatment. CONCLUSIONS: In addition to the characteristics of the oral lesions, 
      information from the clinical profiles of patients with oral PCM is a central 
      tool for dentists for early diagnosis. Earlier diagnosis may result in fewer 
      consequences, especially respiratory ones that may cause an inability to work and 
      poor quality of life.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Dutra, Lais M
AU  - Dutra LM
AD  - Dentristry of Espirito Santo, Vitoria, Brazil. Electronic address: 
      laismdutra@gmail.com.
FAU - Silva, Thiago H M
AU  - Silva THM
AD  - Graduate Dentristry of Espirito Santo Federal University, Vitoria, Brazil. 
      Electronic address: thiago.humbertoms@gmail.com.
FAU - Falqueto, Aloisio
AU  - Falqueto A
AD  - Division of Infectious Diseases, Espirito Santo Federal University, Vitoria, 
      Brazil. Electronic address: falqueto@npd.ufes.br.
FAU - Pecanha, Paulo M
AU  - Pecanha PM
AD  - Department of Clinical Medicine, Espirito Santo Federal University, Vitoria, 
      Brazil. Electronic address: paulo.pecanha@ufes.br.
FAU - Souza, Lucia R M
AU  - Souza LRM
AD  - Department of Pathology, Espirito Santo Federal University, Vitoria, Brazil. 
      Electronic address: lucia.souza@ufes.br.
FAU - Goncalves, Sarah S
AU  - Goncalves SS
AD  - Department of Pathology, Espirito Santo Federal University, Vitoria, Brazil. 
      Electronic address: sarah.tavares@ufes.br.
FAU - Velloso, Tania R G
AU  - Velloso TRG
AD  - Department of Clinical Dentistry, Espirito Santo Federal University, Vitoria, 
      Brazil. Electronic address: taniag.velloso@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20171116
PL  - England
TA  - J Infect Public Health
JT  - Journal of infection and public health
JID - 101487384
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antifungal Agents/*therapeutic use
MH  - Brazil/epidemiology
MH  - Chronic Disease/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gingiva/microbiology/pathology
MH  - Humans
MH  - Male
MH  - Medical Records
MH  - Middle Aged
MH  - Mouth/*microbiology/pathology
MH  - Paracoccidioidomycosis/*drug therapy/*epidemiology/pathology
MH  - Prevalence
MH  - Quality of Life
MH  - Retrospective Studies
MH  - Rural Population
MH  - Smoking/adverse effects
MH  - Ulcer/microbiology/pathology
OTO - NOTNLM
OT  - Clinical manifestations
OT  - Epidemiology
OT  - Oral lesions
OT  - Paracoccidioidomycosis
EDAT- 2017/11/21 06:00
MHDA- 2018/11/10 06:00
CRDT- 2017/11/21 06:00
PHST- 2017/05/26 00:00 [received]
PHST- 2017/10/05 00:00 [revised]
PHST- 2017/10/12 00:00 [accepted]
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2018/11/10 06:00 [medline]
PHST- 2017/11/21 06:00 [entrez]
AID - S1876-0341(17)30284-8 [pii]
AID - 10.1016/j.jiph.2017.10.009 [doi]
PST - ppublish
SO  - J Infect Public Health. 2018 Jul-Aug;11(4):530-533. doi: 
      10.1016/j.jiph.2017.10.009. Epub 2017 Nov 16.