PMID- 29153562
OWN - NLM
STAT- MEDLINE
DCOM- 20191119
LR  - 20220409
IS  - 1876-7591 (Electronic)
IS  - 1876-7591 (Linking)
VI  - 11
IP  - 7
DP  - 2018 Jul
TI  - Noncontrast Myocardial T1 Mapping by Cardiac Magnetic Resonance Predicts Outcome 
      in Patients With Aortic Stenosis.
PG  - 974-983
LID - S1936-878X(17)30908-7 [pii]
LID - 10.1016/j.jcmg.2017.09.005 [doi]
AB  - OBJECTIVES: The aim of this study was to evaluate whether native T1 value of the 
      myocardium on cardiac magnetic resonance (CMR) could predict clinical events in 
      patients with significant aortic stenosis (AS). BACKGROUND: Although previous 
      studies have demonstrated the prognostic value of focal fibrosis using late 
      gadolinium enhancement (LGE) by CMR in AS patients, the prognostic implication of 
      diffuse myocardial fibrosis by noninvasive imaging remains unknown. METHODS: A 
      prospective observational longitudinal study was performed in 127 consecutive 
      patients with moderate or severe AS (68.8 +/- 9.2 years of age, 49.6% male) and 33 
      age- and sex-matched controls who underwent 3-T CMR. The degree of diffuse 
      myocardial fibrosis was assessed by noncontrast mapping of T1 relaxation time 
      using modified Look-Locker inversion-recovery sequence, and the presence and 
      extent of LGE were also evaluated. The AS patients were divided into 3 groups by 
      the native T1 value. Primary endpoint was a composite of all-cause death and 
      hospitalization for heart failure. RESULTS: Native T1 value was higher in AS 
      patients, compared with control subjects (1,232 +/- 53 ms vs. 1,185 +/- 37 ms; 
      p = 0.008). During follow-up (median 27.9 months), there were 24 clinical events 
      including 9 deaths (6 pre-operative and 3 post-operative), the majority of which 
      occurred in the patients in the highest T1 tertile group (2.4% vs. 11.6% 
      vs. 42.9% for lowest, mid-, and highest tertile groups; p < 0.001 by log-rank 
      test). The total number of events for both pre- and post-operative events also 
      occurred more frequently in patients in the highest T1 tertile group. EuroSCORE 
      II, the presence and/or extent of LGE, and the native T1 value were predictors of 
      poor prognosis (adjusted hazard ratio for every 20-ms increase of native T1: 
      1.28; p = 0.003). In particular, the highest native T1 value provided further 
      risk stratification regardless of the presence of LGE. CONCLUSIONS: High native 
      T1 value on noncontrast T1 mapping CMR is a novel, independent predictor of 
      adverse outcome in patients with significant AS.
CI  - Copyright (c) 2018 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Lee, Heesun
AU  - Lee H
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea; Healthcare System Gangnam Center, Seoul National 
      University Hospital, Seoul, Republic of Korea.
FAU - Park, Jun-Bean
AU  - Park JB
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea; Cardiovascular Center, Seoul National University 
      Hospital, Seoul, Republic of Korea.
FAU - Yoon, Yeonyee E
AU  - Yoon YE
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea; Department of Cardiology, Cardiovascular Center, Seoul 
      National University Bundang Hospital, Seongnam, Republic of Korea.
FAU - Park, Eun-Ah
AU  - Park EA
AD  - Department of Radiology, Seoul National University Hospital, Seoul, Republic of 
      Korea.
FAU - Kim, Hyung-Kwan
AU  - Kim HK
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea; Cardiovascular Center, Seoul National University 
      Hospital, Seoul, Republic of Korea.
FAU - Lee, Whal
AU  - Lee W
AD  - Department of Radiology, Seoul National University Hospital, Seoul, Republic of 
      Korea.
FAU - Kim, Yong-Jin
AU  - Kim YJ
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea; Cardiovascular Center, Seoul National University 
      Hospital, Seoul, Republic of Korea.
FAU - Cho, Goo-Yeong
AU  - Cho GY
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea; Department of Cardiology, Cardiovascular Center, Seoul 
      National University Bundang Hospital, Seongnam, Republic of Korea.
FAU - Sohn, Dae-Won
AU  - Sohn DW
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea; Cardiovascular Center, Seoul National University 
      Hospital, Seoul, Republic of Korea.
FAU - Greiser, Andreas
AU  - Greiser A
AD  - Siemens Healthcare, Erlangen, Germany.
FAU - Lee, Seung-Pyo
AU  - Lee SP
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea; Cardiovascular Center, Seoul National University 
      Hospital, Seoul, Republic of Korea. Electronic address: splee0624@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20171115
PL  - United States
TA  - JACC Cardiovasc Imaging
JT  - JACC. Cardiovascular imaging
JID - 101467978
SB  - IM
CIN - JACC Cardiovasc Imaging. 2018 Jul;11(7):1041-1043. PMID: 29921530
CIN - JACC Cardiovasc Imaging. 2018 Jul;11(7):984-986. PMID: 29976304
MH  - Aged
MH  - Aortic Valve Stenosis/complications/*diagnostic imaging/mortality/therapy
MH  - Case-Control Studies
MH  - Cause of Death
MH  - Female
MH  - Fibrosis
MH  - Heart Failure/etiology/mortality/therapy
MH  - Hospitalization
MH  - Humans
MH  - Longitudinal Studies
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Time Factors
OTO - NOTNLM
OT  - aortic stenosis
OT  - cardiac magnetic resonance
OT  - native T1 mapping
OT  - prognosis
EDAT- 2017/11/21 06:00
MHDA- 2019/11/20 06:00
CRDT- 2017/11/21 06:00
PHST- 2017/04/17 00:00 [received]
PHST- 2017/09/06 00:00 [revised]
PHST- 2017/09/14 00:00 [accepted]
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2019/11/20 06:00 [medline]
PHST- 2017/11/21 06:00 [entrez]
AID - S1936-878X(17)30908-7 [pii]
AID - 10.1016/j.jcmg.2017.09.005 [doi]
PST - ppublish
SO  - JACC Cardiovasc Imaging. 2018 Jul;11(7):974-983. doi: 10.1016/j.jcmg.2017.09.005. 
      Epub 2017 Nov 15.