PMID- 29154939 OWN - NLM STAT- MEDLINE DCOM- 20190207 LR - 20190215 IS - 1873-7528 (Electronic) IS - 0149-7634 (Linking) VI - 86 DP - 2018 Mar TI - Hypothesis for cognitive effects of transcranial direct current stimulation: Externally- and internally-directed cognition. PG - 226-238 LID - S0149-7634(17)30004-0 [pii] LID - 10.1016/j.neubiorev.2017.11.006 [doi] AB - A comprehensive explanation is lacking for the broad array of cognitive effects modulated by transcranial direct current stimulation (tDCS). We advanced the testable hypothesis that tDCS to the default mode network (DMN) increases processing of goals and stored information at the expense of external events. We further hypothesized that tDCS to the dorsal attention network (DAN) increases processing of external events at the expense of goals and stored information. A literature search (PsychINFO) identified 42 empirical studies and 3 meta-analyses examining effects of prefrontal and/or parietal tDCS on tasks that selectively required external and/or internal processing. Most, though not all, of the studies that met our search criteria supported our hypothesis. Three meta-analyses supported our hypothesis. The hypothesis we advanced provides a framework for the design and interpretation of results in light of the role of large-scale intrinsic networks that govern attention. CI - Copyright (c) 2017 Elsevier Ltd. All rights reserved. FAU - Greenwood, Pamela M AU - Greenwood PM AD - The ARCH Laboratory, Psychology Department, George Mason University, MSN 3F5, 4400 University Drive, Fairfax, VA, United States. Electronic address: pgreenw1@gmu.edu. FAU - Blumberg, Eric J AU - Blumberg EJ AD - The ARCH Laboratory, Psychology Department, George Mason University, MSN 3F5, 4400 University Drive, Fairfax, VA, United States. FAU - Scheldrup, Melissa R AU - Scheldrup MR AD - The ARCH Laboratory, Psychology Department, George Mason University, MSN 3F5, 4400 University Drive, Fairfax, VA, United States. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20171115 PL - United States TA - Neurosci Biobehav Rev JT - Neuroscience and biobehavioral reviews JID - 7806090 SB - IM MH - Attention/*physiology MH - Cognition/*physiology MH - Humans MH - Neural Pathways/*physiology MH - Parietal Lobe/*physiology MH - Prefrontal Cortex/physiology MH - *Psychological Theory MH - *Transcranial Direct Current Stimulation OTO - NOTNLM OT - Cognition OT - Default mode network OT - Dorsal attention network OT - Hypothesis OT - Parietal cortex OT - Prefrontal cortex OT - Transcranial direct current stimulation EDAT- 2017/11/21 06:00 MHDA- 2019/02/08 06:00 CRDT- 2017/11/21 06:00 PHST- 2017/01/14 00:00 [received] PHST- 2017/11/13 00:00 [revised] PHST- 2017/11/14 00:00 [accepted] PHST- 2017/11/21 06:00 [pubmed] PHST- 2019/02/08 06:00 [medline] PHST- 2017/11/21 06:00 [entrez] AID - S0149-7634(17)30004-0 [pii] AID - 10.1016/j.neubiorev.2017.11.006 [doi] PST - ppublish SO - Neurosci Biobehav Rev. 2018 Mar;86:226-238. doi: 10.1016/j.neubiorev.2017.11.006. Epub 2017 Nov 15.