PMID- 29155120 OWN - NLM STAT- MEDLINE DCOM- 20180504 LR - 20221207 IS - 1872-8227 (Electronic) IS - 0168-8227 (Linking) VI - 135 DP - 2018 Jan TI - Risk of type 2 diabetes mellitus associated with plasma lipid levels: The rural Chinese cohort study. PG - 150-157 LID - S0168-8227(17)30617-4 [pii] LID - 10.1016/j.diabres.2017.11.011 [doi] AB - AIM: To investigate the association of type 2 diabetes mellitus (T2DM) risk and plasma lipid levels in rural Chinese. METHODS: Each lipid variable was divided into quartiles and dichotomized by clinical cutoff points. Cox proportional-hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of T2DM risk and plasma lipid levels and explore the interaction between plasma lipid levels and other risk factors. RESULTS: 11,929 participants were included in the analysis. We documented 720 incident cases of T2DM over 70,720.84 person-years of follow-up, for an incidence of 10.18/1,000 person-years. In the multivariable-adjusted model, risk of T2DM was increased with the highest versus lowest quartiles of total cholesterol (TC) and triglycerides (TG) levels and TC/high-density lipoprotein-cholesterol (HDL-C) and TG/HDL-C ratios. The HRs (95% CIs) for the fourth quartiles, for example, were 1.34 (1.03-1.74), 2.32 (1.73-3.13), 1.66 (1.23-2.25), and 1.84 (1.38-2.45), respectively. In addition, risk of T2DM was increased with high TG level and TC/HDL-C and TG/HDL-C ratios by clinical cutoffs. The HRs (95% CIs) were 1.50 (1.25-1.80), 1.24 (1.03-1.48), and 1.44 (1.18-1.75), respectively. Risk of T2DM was associated with interactions between all lipid variables and age and BMI. TG level and TG/HDL-C ratio additionally interacted with gender (all P(interaction) < 0.0001). CONCLUSIONS: Risk of T2DM was increased with elevated serum levels of TC and TG and TC/HDL-C and TG/HDL-C ratios and also with interactions between high TC and TG levels and TC/HDL-C and TG/HDL-C ratios and age and BMI in a rural Chinese population. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Zhang, Ming AU - Zhang M AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Shenzhen 518060, Guangdong, China. FAU - Zhou, Junmei AU - Zhou J AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Shenzhen 518060, Guangdong, China. FAU - Liu, Yu AU - Liu Y AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, 47 Youyi Road, Shenzhen 518001, Guangdong, China. FAU - Sun, Xizhuo AU - Sun X AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, 47 Youyi Road, Shenzhen 518001, Guangdong, China. FAU - Luo, Xinping AU - Luo X AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Shenzhen 518060, Guangdong, China. FAU - Han, Chengyi AU - Han C AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Shenzhen 518060, Guangdong, China; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, Henan, China. FAU - Zhang, Lu AU - Zhang L AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Shenzhen 518060, Guangdong, China; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, Henan, China. FAU - Wang, Bingyuan AU - Wang B AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Shenzhen 518060, Guangdong, China; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, Henan, China. FAU - Ren, Yongcheng AU - Ren Y AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Shenzhen 518060, Guangdong, China; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, Henan, China. FAU - Zhao, Yang AU - Zhao Y AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Shenzhen 518060, Guangdong, China; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, Henan, China. FAU - Zhang, Dongdong AU - Zhang D AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Shenzhen 518060, Guangdong, China; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, Henan, China. FAU - Liu, Xuejiao AU - Liu X AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Shenzhen 518060, Guangdong, China; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, Henan, China. FAU - Hu, Dongsheng AU - Hu D AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Shenzhen 518060, Guangdong, China. Electronic address: hud@szu.edu.cn. LA - eng PT - Journal Article DEP - 20171115 PL - Ireland TA - Diabetes Res Clin Pract JT - Diabetes research and clinical practice JID - 8508335 RN - 0 (Lipids) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Asian People MH - Cohort Studies MH - Diabetes Mellitus, Type 2/*blood MH - Female MH - Humans MH - Incidence MH - Lipids/*blood MH - Male MH - Middle Aged MH - Prospective Studies MH - Risk Factors MH - Young Adult OTO - NOTNLM OT - Cohort study OT - Plasma lipid levels OT - Type 2 diabetes mellitus EDAT- 2017/11/21 06:00 MHDA- 2018/05/05 06:00 CRDT- 2017/11/21 06:00 PHST- 2017/04/13 00:00 [received] PHST- 2017/06/08 00:00 [revised] PHST- 2017/11/10 00:00 [accepted] PHST- 2017/11/21 06:00 [pubmed] PHST- 2018/05/05 06:00 [medline] PHST- 2017/11/21 06:00 [entrez] AID - S0168-8227(17)30617-4 [pii] AID - 10.1016/j.diabres.2017.11.011 [doi] PST - ppublish SO - Diabetes Res Clin Pract. 2018 Jan;135:150-157. doi: 10.1016/j.diabres.2017.11.011. Epub 2017 Nov 15.