PMID- 29155302
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20191210
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 192
DP  - 2018 Jan 1
TI  - Repeated exposure to sevoflurane impairs the learning and memory of older male 
      rats.
PG  - 75-83
LID - S0024-3205(17)30602-1 [pii]
LID - 10.1016/j.lfs.2017.11.025 [doi]
AB  - AIMS: Critically ill old patients sometimes require repeated surgical 
      interventions, and thus it is important to determine the influence of repeated 
      exposure to anesthetics on learning and memory. Sevoflurane, a widely used 
      inhalation anesthetic, has few neurological adverse effects and offers a rapid 
      return to consciousness. But the long-term influence of sevoflurane exposure and 
      the effect of repeated sevoflurane exposure on cognition have rarely been 
      reported, and available studies are contradictory. MATERIALS AND METHODS: In the 
      present study, the Morris water maze test was employed to investigate the 
      long-term influence of single (4h) or repeated (2h daily for 5 consecutive days) 
      exposure to 1.5% or 2.5% sevoflurane on the learning ability and memory of old 
      (16-18months old) male rats. Testing was performed from 1day to 4weeks after the 
      last exposure. In the hippocampus, brain derived neurotrophic factor (BDNF), 
      NF-kappaB mRNA, and apoptosis rate were also examined to determine whether cellular 
      biochemical changes related to cognition and memory occurred after single or 
      repeated exposure to sevoflurane. KEY FINDINGS: Repeated exposure to 2.5% 
      sevoflurane decreased hippocampal levels of BDNF protein, enhanced hippocampal 
      levels of NF-kappaB mRNA, and increased the apoptosis rate of pyramidal cells. Single 
      exposure to 2.5% sevoflurane, and repeated exposure to either 1.5% or 2.5% 
      sevoflurane significantly compromised learning and memory of old male rats. 
      SIGNIFICANCE: Repeated exposure to sevoflurane impaired the learning and memory 
      of old male rats, an impairment that was accompanied by cognition-related 
      biochemical changes in the hippocampus.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Guo, Shanbin
AU  - Guo S
AD  - Department of Pharmacy, Shengjing Hospital of China Medical University, No 36, 
      Sanhao Street, Herping District, Shenyang 110004, China.
FAU - Liu, Lidan
AU  - Liu L
AD  - Department of Anaesthesiology, Shengjing Hospital of China Medical University, No 
      36, Sanhao Street, Herping District, Shenyang 110004, China.
FAU - Wang, Cong
AU  - Wang C
AD  - Department of Anaesthesiology, Shengjing Hospital of China Medical University, No 
      36, Sanhao Street, Herping District, Shenyang 110004, China.
FAU - Jiang, Qian
AU  - Jiang Q
AD  - Department of Anaesthesiology, Shengjing Hospital of China Medical University, No 
      36, Sanhao Street, Herping District, Shenyang 110004, China.
FAU - Dong, Yunxia
AU  - Dong Y
AD  - Department of Anaesthesiology, Shengjing Hospital of China Medical University, No 
      36, Sanhao Street, Herping District, Shenyang 110004, China.
FAU - Tian, Yue
AU  - Tian Y
AD  - Department of Anaesthesiology, Shengjing Hospital of China Medical University, No 
      36, Sanhao Street, Herping District, Shenyang 110004, China. Electronic address: 
      tianyue_tougao@yeah.net.
LA  - eng
PT  - Journal Article
DEP - 20171117
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Methyl Ethers)
RN  - 0 (NF-kappa B)
RN  - 38LVP0K73A (Sevoflurane)
SB  - IM
MH  - Aging/*psychology
MH  - Anesthetics, Inhalation/*toxicity
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Brain Chemistry/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition/drug effects
MH  - Hippocampus/drug effects
MH  - Learning Disabilities/*chemically induced/psychology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*chemically induced/psychology
MH  - Methyl Ethers/*toxicity
MH  - NF-kappa B/biosynthesis
MH  - Pyramidal Cells/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sevoflurane
OTO - NOTNLM
OT  - Anesthetics
OT  - Cognition
OT  - Hippocampus
OT  - Neurological adverse effect
EDAT- 2017/11/21 06:00
MHDA- 2018/01/09 06:00
CRDT- 2017/11/21 06:00
PHST- 2017/06/27 00:00 [received]
PHST- 2017/11/08 00:00 [revised]
PHST- 2017/11/16 00:00 [accepted]
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2017/11/21 06:00 [entrez]
AID - S0024-3205(17)30602-1 [pii]
AID - 10.1016/j.lfs.2017.11.025 [doi]
PST - ppublish
SO  - Life Sci. 2018 Jan 1;192:75-83. doi: 10.1016/j.lfs.2017.11.025. Epub 2017 Nov 17.