PMID- 29155501
OWN - NLM
STAT- MEDLINE
DCOM- 20180809
LR  - 20180809
IS  - 1440-1797 (Electronic)
IS  - 1320-5358 (Linking)
VI  - 22 Suppl 4
DP  - 2017 Dec
TI  - Urinary mRNA and lupus disease flare.
PG  - 27-30
LID - 10.1111/nep.13151 [doi]
AB  - In the past 20 years, extraction and quantification of mRNA from urinary sediment 
      has emerged as a novel laboratory technique. The potential application of urinary 
      mRNA quantification to the clinical care of patients with SLE has become an 
      active field of research. However, published studies in this area are limited to 
      small-scale ones. mRNA levels of several of cytokine and transcript factor genes 
      have been found to have the potential for the diagnosis or monitoring of disease 
      activity in patients with lupus nephritis. Our previous studies showed that a 
      high urinary mRNA level of T-bet, the key transcription factor of type 1 T helper 
      cells (Th1), was an independent predictor of lupus flare and probably reflects an 
      intrinsic characteristic of patients with predisposition to Th1 activation. Other 
      studies suggest that monitoring of monocyte chemoattractant protein-1(MCP-1), 
      interleukin (IL)-17, GATA-3 (the key transcription factor of type 2 T helper 
      cells) and forkhead box P3 (FOXP3, the key transcription factor of regulatory T 
      cells) mRNA level in urinary sediment may provide an early clue for detecting 
      disease flare in lupus patients. As a simple and non-invasive method, urinary 
      mRNA level deserves further studies to validate its role in risk stratification 
      and monitoring of patients with lupus nephritis.
CI  - (c) 2017 Asian Pacific Society of Nephrology.
FAU - Szeto, Cheuk-Chun
AU  - Szeto CC
AD  - Department of Medicine & Therapeutics, Prince of Wales Hospital, 32 Ngan Shing 
      Street, Shatin, NT, Hong Kong, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Nephrology (Carlton)
JT  - Nephrology (Carlton, Vic.)
JID - 9615568
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (Interleukin-17)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Biomarkers
MH  - Chemokine CCL2/genetics
MH  - GATA3 Transcription Factor/genetics
MH  - Humans
MH  - Interleukin-17/genetics
MH  - Lupus Nephritis/*urine
MH  - RNA, Messenger/*urine
MH  - Th1 Cells/immunology
OTO - NOTNLM
OT  - SLE
OT  - biomarkers
OT  - glomerulonephritis
EDAT- 2017/11/21 06:00
MHDA- 2018/08/10 06:00
CRDT- 2017/11/21 06:00
PHST- 2017/08/01 00:00 [accepted]
PHST- 2017/11/21 06:00 [entrez]
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2018/08/10 06:00 [medline]
AID - 10.1111/nep.13151 [doi]
PST - ppublish
SO  - Nephrology (Carlton). 2017 Dec;22 Suppl 4:27-30. doi: 10.1111/nep.13151.