PMID- 29155621
OWN - NLM
STAT- MEDLINE
DCOM- 20171127
LR  - 20211204
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Print)
IS  - 0033-8419 (Linking)
VI  - 285
IP  - 3
DP  - 2017 Dec
TI  - Science to Practice: Enhancing Photothermal Ablation of Colorectal Liver 
      Metastases with Targeted Hybrid Nanoparticles.
PG  - 699-701
LID - 10.1148/radiol.2017170993 [doi]
AB  - Image-guided percutaneous thermal ablation has been one of the principal tools in 
      management of unresectable liver malignancies, including colorectal liver 
      metastases (CRLM) ( 1 ). Currently, however, this technique is suitable mainly 
      for tumors less than 4-5 cm in diameter and also results in incomplete ablation 
      at tumor margins ( 2 ). To solve these problems, efforts have been made to 
      combine thermal ablation with other treatment options, such as systemic and 
      intra-arterial administration of therapeutics ( 3 - 5 ). In this issue of 
      Radiology, White et al ( 6 ) introduced their work on development of an 
      alternative approach by using biofunctionalized hybrid magnetic gold 
      nanoparticles (HNPs) as catalysts for photothermal ablation of CRLM. They found 
      that (a) the targeted (anti-MG1) HNPs are noncytotoxic and have greater than 20% 
      intratumoral accumulation and (b) systemic administration of anti-MG1 HNPs can 
      enlarge a tumor's necrotic zone with photothermal ablation. The results of this 
      study establish the proof of the concept that targeted HNPs can enhance the 
      therapeutic effect of photothermal ablation, which presents an exciting strategy 
      for complete removal of CRLM by integrating two rapidly advancing scientific 
      fields-interventional radiology and nanotechnology.
FAU - Yang, Xiaoming
AU  - Yang X
AD  - Image-Guided Bio-Molecular Interventions Research and Division of Interventional 
      Radiology, Department of Radiology University of Washington School of Medicine 
      815 Mercer St, Room S470, Campus Box 358056 Seattle, WA 98109.
LA  - eng
GR  - R01 EB012467/EB/NIBIB NIH HHS/United States
GR  - R01 EB028095/EB/NIBIB NIH HHS/United States
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Nanoconjugates)
SB  - IM
CON - Radiology. 2017 Dec;285(3):809-819. PMID: 28707960
MH  - Animals
MH  - Biological Science Disciplines/trends
MH  - Colorectal Neoplasms/pathology/*secondary/*therapy
MH  - Humans
MH  - Hyperthermia, Induced/trends
MH  - Liver Neoplasms/*pathology/therapy
MH  - Molecular Targeted Therapy/*trends
MH  - Nanoconjugates/chemistry/*therapeutic use
MH  - Phototherapy/*trends
MH  - Translational Research, Biomedical/*trends
MH  - Treatment Outcome
PMC - PMC5708282
EDAT- 2017/11/21 06:00
MHDA- 2017/11/29 06:00
PMCR- 2018/12/01
CRDT- 2017/11/21 06:00
PHST- 2017/11/21 06:00 [entrez]
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 10.1148/radiol.2017170993 [doi]
PST - ppublish
SO  - Radiology. 2017 Dec;285(3):699-701. doi: 10.1148/radiol.2017170993.