PMID- 29155861
OWN - NLM
STAT- MEDLINE
DCOM- 20171206
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 11
DP  - 2017
TI  - Pancreatic exocrine insufficiency in patients with chronic heart failure and its 
      possible association with appetite loss.
PG  - e0187804
LID - 10.1371/journal.pone.0187804 [doi]
LID - e0187804
AB  - BACKGROUND: Appetite loss is one complication of chronic heart failure (CHF), and 
      its association with pancreatic exocrine insufficiency (PEI) is not well 
      investigated in CHF. AIM: We attempted to detect the association between PEI and 
      CHF-induced appetite. METHODS: Patients with CHF were enrolled, and body mass 
      index (BMI), left ventricular ejection fraction (LVEF), New York Heart 
      Association (NYHA) cardiac function grading, B-type natriuretic peptide (BNP), 
      serum albumin, pro-albumin and hemoglobin were evaluated. The pancreatic exocrine 
      function was measured by fecal elastase-1 (FE-1) levels in the enrolled patients. 
      Appetite assessment was tested by completing the simplified nutritional appetite 
      questionnaire (SNAQ). The improvement of appetite loss by supplemented pancreatic 
      enzymes was also researched in this study. RESULTS: The decrease of FE-1 levels 
      was found in patients with CHF, as well as SNAQ scores. A positive correlation 
      was observed between SNAQ scores and FE-1 levels (r = 0.694, p < 0.001). 
      Pancreatic enzymes supplement could attenuate the decrease of SNAQ scores in CHF 
      patients with FE-1 levels <200 mug/g stool and SNAQ < 14. CONCLUSIONS: Appetite 
      loss is commonly seen in CHF, and is partially associated with pancreatic 
      exocrine insufficiency. Oral pancreatic enzyme replacement therapy attenuates the 
      chronic heart failure-induced appetite loss. These results suggest a possible 
      pancreatic-cardiac relationship in chronic heart failure, and further experiment 
      is needed for clarifying the possible mechanisms.
FAU - Xia, Tingting
AU  - Xia T
AD  - Department of Gastroenterology, The First Affiliated Hospital of Soochow 
      University, Canglang District, Suzhou, Jiangsu Province, China.
FAU - Chai, Xichen
AU  - Chai X
AD  - Department of Cardiology, The First Affiliated Hospital of Soochow University, 
      Canglang District, Suzhou, Jiangsu Province, China.
FAU - Shen, Jiaqing
AU  - Shen J
AUID- ORCID: 0000-0002-8600-4859
AD  - Department of Gastroenterology, The First Affiliated Hospital of Soochow 
      University, Canglang District, Suzhou, Jiangsu Province, China.
LA  - eng
PT  - Journal Article
DEP - 20171120
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Hemoglobins)
RN  - 0 (Pancreatic Extracts)
RN  - 0 (Serum Albumin)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anorexia/complications/drug therapy/*physiopathology
MH  - Appetite/*drug effects/physiology
MH  - Body Mass Index
MH  - Enzyme Replacement Therapy
MH  - Exocrine Pancreatic Insufficiency/complications/drug therapy/*physiopathology
MH  - Female
MH  - Heart Failure/complications/drug therapy/*physiopathology
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Pancreatic Extracts/administration & dosage
MH  - Serum Albumin/metabolism
MH  - Surveys and Questionnaires
MH  - Ventricular Function, Left/physiology
PMC - PMC5695817
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/11/21 06:00
MHDA- 2017/12/07 06:00
PMCR- 2017/11/20
CRDT- 2017/11/21 06:00
PHST- 2017/04/09 00:00 [received]
PHST- 2017/10/26 00:00 [accepted]
PHST- 2017/11/21 06:00 [entrez]
PHST- 2017/11/21 06:00 [pubmed]
PHST- 2017/12/07 06:00 [medline]
PHST- 2017/11/20 00:00 [pmc-release]
AID - PONE-D-17-10668 [pii]
AID - 10.1371/journal.pone.0187804 [doi]
PST - epublish
SO  - PLoS One. 2017 Nov 20;12(11):e0187804. doi: 10.1371/journal.pone.0187804. 
      eCollection 2017.