PMID- 29156916
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20181202
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 6
IP  - Suppl 2
DP  - 2017 Dec
TI  - A critical evaluation of quality of life in clinical trials of breast cancer 
      patients treated with radiation therapy.
PG  - S223-S232
LID - 10.21037/apm.2017.09.06 [doi]
AB  - The aim of this study was to investigate the extent to which health-related 
      quality of life (HRQOL) parameters have been reported in phase III trials with 
      breast cancer patients (BCPs) who received radiation therapy (RT). We also 
      examine the frequency and correlates of significant HRQOL gains. A systematic 
      review was conducted. When HRQOL was a study endpoint, we extracted data on the 
      instruments used for HRQOL analysis, assessing if there was formal statistical 
      comparison between study groups and the results of such comparisons as reported 
      by the authors of the studies. In result, 182 trials were included. HRQOL was 
      considered as endpoint in 38 (20.8%) of the studies and it was used as primary 
      endpoint in 10.9% of them. Of 22 trials that had a positive primary endpoint, 18 
      had a significant benefit in HRQOL, in favor of the experimental arm. Of 13 
      trials that had a negative primary endpoint, there were no differences in HRQOL 
      among the study groups. With respect to HRQOL assessment, statistical methods and 
      definition of timing of evaluation were described in 32 (84.2%) and 36 (94.7%) 
      trials, respectively. In conclusion, HRQOL has been infrequently investigated in 
      trials in BCP who received RT. Statistical methods and timing of evaluation were 
      infrequently described with sufficient detail to be informative.
FAU - Marta, Gustavo N
AU  - Marta GN
AD  - Department of Radiation Oncology, Hospital Sirio-Libanes, Sao Paulo, Brazil; 
      Department of Radiology and Oncology of University of Sao Paulo, Radiation 
      Oncology Unit, Instituto do Cancer do Estado de Sao Paulo (ICESP), Faculdade de 
      Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil. 
      gustavo.marta@hc.fm.usp.br.
FAU - Moraes, Fabio Y
AU  - Moraes FY
AD  - Radiation Medicine Program, Princess Margaret Cancer Centre, University Health 
      Network, Toronto, ON, Canada.
FAU - Leite, Elton T T
AU  - Leite ETT
AD  - Department of Radiation Oncology, Hospital Sirio-Libanes, Sao Paulo, Brazil; 
      Department of Radiology and Oncology of University of Sao Paulo, Radiation 
      Oncology Unit, Instituto do Cancer do Estado de Sao Paulo (ICESP), Faculdade de 
      Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Chow, Edward
AU  - Chow E
AD  - Sunnybrook Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of 
      Toronto, Toronto, Canada.
FAU - Cella, David
AU  - Cella D
AD  - Department of Medical Social Sciences, Northwestern University, Illinois, USA.
FAU - Bottomley, Andrew
AU  - Bottomley A
AD  - European Organisation for Research and Treatment of Cancer, Brussels, Belgium.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20171024
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
SB  - IM
MH  - Breast Neoplasms/psychology/*radiotherapy
MH  - Clinical Trials, Phase III as Topic
MH  - Female
MH  - Humans
MH  - *Quality of Life
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Quality of life (QOL)
OT  - breast cancer
OT  - radiation therapy (RT)
OT  - treatment
EDAT- 2017/11/22 06:00
MHDA- 2018/08/14 06:00
CRDT- 2017/11/22 06:00
PHST- 2017/09/12 00:00 [received]
PHST- 2017/09/17 00:00 [accepted]
PHST- 2017/11/22 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PHST- 2017/11/22 06:00 [entrez]
AID - apm.2017.09.06 [pii]
AID - 10.21037/apm.2017.09.06 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2017 Dec;6(Suppl 2):S223-S232. doi: 10.21037/apm.2017.09.06. 
      Epub 2017 Oct 24.