PMID- 29158111
OWN - NLM
STAT- MEDLINE
DCOM- 20180807
LR  - 20180807
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 339
DP  - 2018 Feb 26
TI  - Brain-derived neurotrophic factor (BDNF) determines a sex difference in 
      cue-conditioned alcohol seeking in rats.
PG  - 73-78
LID - S0166-4328(17)31617-0 [pii]
LID - 10.1016/j.bbr.2017.11.019 [doi]
AB  - Alcohol use disorder is a detrimental addictive disease that develops through 
      prolonged ethanol exposure and regular intoxication. However, the changes in the 
      underlying neurobiology leading to alcohol addiction remain unclear. 
      Brain-Derived Neurotrophic Factor (BDNF) is implicated in substance abuse 
      disorders including alcoholism. As the vast majority of previous animal model 
      studies have concentrated on males only, the aim of this study was to determine 
      whether endogenous BDNF mediates alcohol seeking in a sex-specific manner. We 
      used an operant self-administration paradigm where the animals were trained in 
      operant chambers to self-administer a 10% ethanol solution, and compared male and 
      female BDNF heterozygous (HET) and wildtype (WT) rats. Over several weeks, the 
      animals progressed through acquisition, progressive ratio, extinction, and 
      reinstatement phases. There were no significant sex or genotype differences in 
      the number of alcohol-paired lever presses during acquisition, progressive ratio 
      and extinction. However, a significant difference between male and female WT rats 
      following alcohol-primed reinstatement was completely absent in BDNF HET rats 
      suggesting a role of BDNF in sex differences in alcohol seeking after abstinence. 
      Female BDNF HET rats showed significantly higher number of alcohol-paired lever 
      presses during reinstatement than female WT controls. These findings suggest that 
      BDNF regulatory pathways are involved in sex differences in reinstatement of 
      alcohol intake and emphasize the need to include both male and female animals to 
      explore sex-specific interactions in addiction neurocircuitry.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Hogarth, Samuel J
AU  - Hogarth SJ
AD  - School of Psychology and Public Health, Department of Psychology, La Trobe 
      University, Bundoora, Australia.
FAU - Jaehne, Emily J
AU  - Jaehne EJ
AD  - School of Psychology and Public Health, Department of Psychology, La Trobe 
      University, Bundoora, Australia.
FAU - van den Buuse, Maarten
AU  - van den Buuse M
AD  - School of Psychology and Public Health, Department of Psychology, La Trobe 
      University, Bundoora, Australia; Department of Pharmacology, University of 
      Melbourne, Australia; The College of Public Health, Medical and Veterinary 
      Sciences, James Cook University, Townsville, Australia. Electronic address: 
      m.vandenbuuse@latrobe.edu.au.
FAU - Djouma, Elvan
AU  - Djouma E
AD  - School of Life Sciences, Department of Physiology, Anatomy and Microbiology, La 
      Trobe University, Bundoora, Australia.
LA  - eng
PT  - Journal Article
DEP - 20171121
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Behavior, Addictive/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cocaine/administration & dosage/*pharmacology
MH  - Conditioning, Operant/drug effects
MH  - Extinction, Psychological/drug effects
MH  - Rats, Sprague-Dawley
MH  - Self Administration
MH  - *Sex Characteristics
MH  - Substance-Related Disorders
OTO - NOTNLM
OT  - Alcohol seeking
OT  - Brain-derived neurotrophic factor
OT  - Extinction
OT  - Reinstatement
OT  - Sex differences
EDAT- 2017/11/22 06:00
MHDA- 2018/08/08 06:00
CRDT- 2017/11/22 06:00
PHST- 2017/09/28 00:00 [received]
PHST- 2017/11/14 00:00 [revised]
PHST- 2017/11/16 00:00 [accepted]
PHST- 2017/11/22 06:00 [pubmed]
PHST- 2018/08/08 06:00 [medline]
PHST- 2017/11/22 06:00 [entrez]
AID - S0166-4328(17)31617-0 [pii]
AID - 10.1016/j.bbr.2017.11.019 [doi]
PST - ppublish
SO  - Behav Brain Res. 2018 Feb 26;339:73-78. doi: 10.1016/j.bbr.2017.11.019. Epub 2017 
      Nov 21.