PMID- 29158882
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220310
IS  - 2008-126X (Print)
IS  - 2228-7442 (Electronic)
IS  - 2008-126X (Linking)
VI  - 8
IP  - 4
DP  - 2017 Jul-Aug
TI  - The Mediating Role of A(2A) Adenosine Receptors in the Mitochondrial Pathway of 
      Apoptotic Hippocampal Cell Death, Following the Administration of MDMA in Rat.
PG  - 317-324
LID - 10.18869/nirp.bcn.8.4.317 [doi]
AB  - INTRODUCTION: The 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is a popular 
      recreational drug and a major source of substance abuse, which ultimately leads 
      to sensations of well-being, elation and euphoria, moderate 
      derealization/depersonalization, and cognitive disruptions, as well as intense 
      sensory awareness. The mechanisms involved in memory impairment induced by MDMA 
      are not completely understood. METHODS: The current study used 40 Sprague-Dawley 
      rats, weighted 200 to 250 g. Experiments were performed in four groups, each 
      containing 10 rats. The first group of rats was used as the control, treated with 
      dimethyl sulfoxide (DMSO). The second group was treated with MDMA. The third 
      group was treated with MDMA and CGS (the adenosine A(2A) receptor agonist, 
      2-[p-(2-carboxyethyl) phenethylamino]-5'-N-ethylcarboxamidoadenosine) (CGS 21680) 
      and the fourth group was treated with MDMA and SCH (the A(2A) receptor antagonist 
      [7-(2-phenylethyl)-5-amino-2-(2-furyl-) pyrazolo-[4, 3-e]-1, 2, 4 triazolo [1,5-] 
      pyrimidine]) (SCH 58261). The drugs in all groups were administrated 
      intraperitoneally (i.p.) once a day for 7 days. In 5 rats of each group, 
      following perfusion, samples were taken from hippocampi to investigate apoptosis. 
      Accordingly, the samples were stained using the terminal deoxynucleotidyl 
      transferase-mediated dUTP nick end labeling (TUNEL) assay kit, and studied by 
      light microscopy. In other rats, fresh tissue was also removed to study the 
      expression of bax and bcl-2 by Western blotting technique. RESULTS: It was 
      observed that the coadministration of MDMA with CGS reduced bax expression and 
      prevented apoptosis of hippocampal cells. The coadministration of MDMA and SCH 
      increased bax expression, and also increased the frequency of hippocampal cell 
      apoptosis. CONCLUSION: The results of the current study showed that 
      administration of CGS with MDMA decreased the common side effects associated with 
      MDMA.
FAU - Bakhshayesh, Masoomeh
AU  - Bakhshayesh M
AD  - Cellular and Molecular Research Center, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Golab, Fereshteh
AU  - Golab F
AD  - Cellular and Molecular Research Center, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Kermanian, Fatemeh
AU  - Kermanian F
AD  - Department of Anatomy, School of Medicine, Alborz University of Medical Sciences, 
      Karaj, Iran.
FAU - Mehdizadeh, Mehdi
AU  - Mehdizadeh M
AD  - Cellular and Molecular Research Center, Iran University of Medical Sciences, 
      Tehran, Iran.
AD  - Department of Anatomy, School of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Katebi, Amir Reza
AU  - Katebi AR
AD  - Department of Educational Psychology, Faculty of Psychology & Educational 
      Sciences, Allameh Tabataba'i University, Tehran, Iran.
FAU - Soleimani, Mansooreh
AU  - Soleimani M
AD  - Cellular and Molecular Research Center, Iran University of Medical Sciences, 
      Tehran, Iran.
AD  - Department of Anatomy, School of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Mohammadzadeh, Farzaneh
AU  - Mohammadzadeh F
AD  - Department of Anatomy, School of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Shabani, Ronak
AU  - Shabani R
AD  - Cellular and Molecular Research Center, Iran University of Medical Sciences, 
      Tehran, Iran.
AD  - Department of Anatomy, School of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Movahed, Elham
AU  - Movahed E
AD  - Department of Anatomy, School of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Katebi, Majid
AU  - Katebi M
AD  - Cellular and Molecular Research Center, Iran University of Medical Sciences, 
      Tehran, Iran.
AD  - Department of Anatomy, School of Medicine, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Basic Clin Neurosci
JT  - Basic and clinical neuroscience
JID - 101575211
PMC - PMC5683689
OTO - NOTNLM
OT  - Adenosine receptor
OT  - Agonist of A2A receptor
OT  - Antagonist of A2A receptor
OT  - Ecstasy or MDMA
OT  - Neurotoxicity
COIS- Conflict of Interest The authors declared no conflicts of interest.
EDAT- 2017/11/22 06:00
MHDA- 2017/11/22 06:01
PMCR- 2017/07/01
CRDT- 2017/11/22 06:00
PHST- 2017/11/22 06:00 [entrez]
PHST- 2017/11/22 06:00 [pubmed]
PHST- 2017/11/22 06:01 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - bcn-8-317 [pii]
AID - 10.18869/nirp.bcn.8.4.317 [doi]
PST - ppublish
SO  - Basic Clin Neurosci. 2017 Jul-Aug;8(4):317-324. doi: 10.18869/nirp.bcn.8.4.317.