PMID- 29159045 OWN - NLM STAT- MEDLINE DCOM- 20180629 LR - 20210126 IS - 2213-1582 (Electronic) IS - 2213-1582 (Linking) VI - 17 DP - 2018 TI - Identifying functional network changing patterns in individuals at clinical high-risk for psychosis and patients with early illness schizophrenia: A group ICA study. PG - 335-346 LID - S2213-1582(17)30259-0 [pii] LID - 10.1016/j.nicl.2017.10.018 [doi] AB - Although individuals at clinical high risk (CHR) for psychosis exhibit a psychosis-risk syndrome involving attenuated forms of the positive symptoms typical of schizophrenia (SZ), it remains unclear whether their resting-state brain intrinsic functional networks (INs) show attenuated or qualitatively distinct patterns of functional dysconnectivity relative to SZ patients. Based on resting-state functional magnetic imaging data from 70 healthy controls (HCs), 53 CHR individuals (among which 41 subjects were antipsychotic medication-naive), and 58 early illness SZ (ESZ) patients (among which 53 patients took antipsychotic medication) within five years of illness onset, we estimated subject-specific INs using a novel group information guided independent component analysis (GIG-ICA) and investigated group differences in INs. We found that when compared to HCs, both CHR and ESZ groups showed significant differences, primarily in default mode, salience, auditory-related, visuospatial, sensory-motor, and parietal INs. Our findings suggest that widespread INs were diversely impacted. More than 25% of voxels in the identified significant discriminative regions (obtained using all 19 possible changing patterns excepting the no-difference pattern) from six of the 15 interrogated INs exhibited monotonically decreasing Z-scores (in INs) from the HC to CHR to ESZ, and the related regions included the left lingual gyrus of two vision-related networks, the right postcentral cortex of the visuospatial network, the left thalamus region of the salience network, the left calcarine region of the fronto-occipital network and fronto-parieto-occipital network. Compared to HCs and CHR individuals, ESZ patients showed both increasing and decreasing connectivity, mainly hypo-connectivity involving 15% of the altered voxels from four INs. The left supplementary motor area from the sensory-motor network and the right inferior occipital gyrus in the vision-related network showed a common abnormality in CHR and ESZ groups. Some brain regions also showed a CHR-unique alteration (primarily the CHR-increasing connectivity). In summary, CHR individuals generally showed intermediate connectivity between HCs and ESZ patients across multiple INs, suggesting that some dysconnectivity patterns evident in ESZ predate psychosis in attenuated form during the psychosis risk stage. Hence, these connectivity measures may serve as possible biomarkers to predict schizophrenia progression. FAU - Du, Yuhui AU - Du Y AD - The Mind Research Network, Albuquerque, NM, USA; Shanxi University, School of Computer & Information Technology, Taiyuan, China. Electronic address: ydu@mrn.org. FAU - Fryer, Susanna L AU - Fryer SL AD - Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA; The Mental Health Service, San Francisco VA Healthcare System, San Francisco, CA, USA. FAU - Lin, Dongdong AU - Lin D AD - The Mind Research Network, Albuquerque, NM, USA. FAU - Sui, Jing AU - Sui J AD - The Mind Research Network, Albuquerque, NM, USA; Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China. FAU - Yu, Qingbao AU - Yu Q AD - The Mind Research Network, Albuquerque, NM, USA. FAU - Chen, Jiayu AU - Chen J AD - The Mind Research Network, Albuquerque, NM, USA. FAU - Stuart, Barbara AU - Stuart B AD - Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA. FAU - Loewy, Rachel L AU - Loewy RL AD - Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA. FAU - Calhoun, Vince D AU - Calhoun VD AD - The Mind Research Network, Albuquerque, NM, USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA. FAU - Mathalon, Daniel H AU - Mathalon DH AD - Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA; The Mental Health Service, San Francisco VA Healthcare System, San Francisco, CA, USA. Electronic address: daniel.mathalon@ucsf.edu. LA - eng GR - R01 EB006841/EB/NIBIB NIH HHS/United States GR - R01 MH076989/MH/NIMH NIH HHS/United States GR - P20 RR021938/RR/NCRR NIH HHS/United States GR - R01 EB020407/EB/NIBIB NIH HHS/United States GR - P20 GM103472/GM/NIGMS NIH HHS/United States GR - R01 MH118695/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20171019 PL - Netherlands TA - Neuroimage Clin JT - NeuroImage. Clinical JID - 101597070 RN - 0 (Antipsychotic Agents) SB - IM MH - Adult MH - Antipsychotic Agents/therapeutic use MH - Brain/diagnostic imaging/*physiopathology MH - Brain Mapping/methods MH - Disease Progression MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Neural Pathways/diagnostic imaging/physiopathology MH - Psychotic Disorders/diagnostic imaging/*physiopathology MH - Risk Factors MH - Schizophrenia/diagnostic imaging/drug therapy/*physiopathology MH - Young Adult PMC - PMC5681342 OTO - NOTNLM OT - Brain intrinsic functional networks OT - Functional magnetic resonance imaging OT - Independent component analysis OT - Psychosis-risk syndrome OT - Resting-state OT - Schizophrenia EDAT- 2017/11/22 06:00 MHDA- 2018/06/30 06:00 PMCR- 2017/10/19 CRDT- 2017/11/22 06:00 PHST- 2017/05/30 00:00 [received] PHST- 2017/09/13 00:00 [revised] PHST- 2017/10/18 00:00 [accepted] PHST- 2017/11/22 06:00 [entrez] PHST- 2017/11/22 06:00 [pubmed] PHST- 2018/06/30 06:00 [medline] PHST- 2017/10/19 00:00 [pmc-release] AID - S2213-1582(17)30259-0 [pii] AID - 10.1016/j.nicl.2017.10.018 [doi] PST - epublish SO - Neuroimage Clin. 2017 Oct 19;17:335-346. doi: 10.1016/j.nicl.2017.10.018. eCollection 2018.