PMID- 2916232
OWN - NLM
STAT- MEDLINE
DCOM- 19890323
LR  - 20190727
IS  - 0041-008X (Print)
IS  - 0041-008X (Linking)
VI  - 97
IP  - 1
DP  - 1989 Jan
TI  - Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three 
      polychlorinated dibenzofurans.
PG  - 156-66
AB  - Polychlorinated dibenzodioxins (PCDDs) and dibenzofurans (PCDFs) are toxic 
      environmental contaminants which have the potential to accumulate in human 
      tissues. In order to examine the potential for systemic exposure following dermal 
      exposure, the absorption, distribution, and elimination of 
      2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzofuran 
      (TCDF), 1,2,3,7,8-pentachlorodibenzofuran (1PeCDF), and 
      2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) were evaluated in male F344 rats. TCDD 
      (0.00015, 0.001, 0.01, 0.1, 0.5, and 1.0 mumol/kg) and the three PCDFs (0.1, 0.5, 
      and 1.0 mumol/kg) were applied to a preclipped region on the back of the rat and 
      covered with a perforated cap. The rats were held in individual metabolism cages 
      for 3 days. In animals administered 0.1 mumol/kg, the absorption of TCDF was 
      greater than that of 4PeCDF, 1PeCDF, and TCDD. Relative absorption (percentage of 
      administered dose) declined with increasing dose while the absolute absorption 
      (microgram/kg) increased nonlinearly with dose. Absorption of TCDF at 0.1 
      mumol/kg was 48% of the administered dose which was significantly greater than 
      that of the other compounds. At this dose, absorption of 4PeCDF was greater than 
      that of TCDD. Absorption at the higher doses was similar for all four compounds. 
      Maximum relative absorption of TCDD (approximately 40% of the administered dose) 
      was obtained at 0.001 and 0.00015 mumol/kg. Major tissue depots for these four 
      chemicals included liver, adipose, skin, and muscle tissue; however, the 
      liver:fat ratio for 4PeCDF was approximately fourfold higher than that for the 
      other three compounds. When normalized to 100% of dose absorbed, the distribution 
      of 4PeCDF-derived radioactivity in liver and adipose tissue was similar to that 
      previously observed after oral and iv administration. In animals administered 0.1 
      mumol TCDF or 1PeCDF/kg, 56 and 32% of the respective absorbed dose was excreted 
      as polar metabolites within 3 days. Very little of the absorbed dose of either 
      TCDD (approximately 10%) or 4PeCDF (approximately 2%) was eliminated. Results 
      indicate that the dermal absorption of these compounds is incomplete and that 
      systemic toxicity following acute dermal exposure to levels found in the 
      environment is unlikely.
FAU - Brewster, D W
AU  - Brewster DW
AD  - Systemic Toxicology Branch, National Institute of Environmental Health Sciences, 
      Triangle Park, North Carolina 27709.
FAU - Banks, Y B
AU  - Banks YB
FAU - Clark, A M
AU  - Clark AM
FAU - Birnbaum, L S
AU  - Birnbaum LS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Benzofurans)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Industrial Waste)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Polymers)
RN  - 0 (polychlorodibenzofuran)
RN  - QNE7ZLB7SS (1,2,3,7,8-pentachlorodibenzofuran)
RN  - U4C2RV3124 (2,3,4,7,8-pentachlorodibenzofuran)
RN  - XZJ41GQI5D (2,3,7,8-tetrachlorodibenzofuran)
SB  - IM
MH  - Administration, Cutaneous
MH  - Animals
MH  - Benzofurans/analysis/*pharmacokinetics
MH  - Dioxins/*pharmacokinetics
MH  - Dose-Response Relationship, Drug
MH  - Environmental Pollutants/*analysis
MH  - Feces/analysis
MH  - Industrial Waste/analysis
MH  - Male
MH  - Polychlorinated Dibenzodioxins/analysis/*pharmacokinetics
MH  - *Polymers
MH  - Rats
MH  - Rats, Inbred F344
MH  - *Skin Absorption
MH  - Tissue Distribution
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 0041-008X(89)90064-1 [pii]
AID - 10.1016/0041-008x(89)90064-1 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 1989 Jan;97(1):156-66. doi: 10.1016/0041-008x(89)90064-1.